Intraocular dapiprazole for the reversal of mydriasis after extracapsular cataract extraction with intraocular lens implantation. Part I: Dose-response correlation

Dapiprazole, an alpha-blocking miotic drug, was used intracamerally at the end of extracapsular cataract extraction with posterior chamber intraocular lens (IOL) implantation. The double-blind study included 120 patients divided into four groups of 30 eyes; the groups received balanced salt solution...

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Bibliographic Details
Published inJournal of cataract and refractive surgery Vol. 17; no. 6; p. 780
Main Authors Ponte, F, Cillino, S, Faranda, F, Casanova, F, Cucci, F
Format Journal Article
LanguageEnglish
Published United States 01.11.1991
Subjects
Adrenergic alpha-Antagonists - administration & dosage
Adult
Aged
Aged, 80 and over
Anterior Chamber - drug effects
Cataract Extraction
Dose-Response Relationship, Drug
Double-Blind Method
Female
Follow-Up Studies
Humans
Lenses, Intraocular
Male
Middle Aged
Piperazines
Postoperative Care
Pupil - drug effects
Triazoles - administration & dosage
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Summary:Dapiprazole, an alpha-blocking miotic drug, was used intracamerally at the end of extracapsular cataract extraction with posterior chamber intraocular lens (IOL) implantation. The double-blind study included 120 patients divided into four groups of 30 eyes; the groups received balanced salt solution, 0.125%, 0.25%, or 0.5% intraocular dapiprazole after IOL implantation and before suturing. Pupillary diameter recordings were performed immediately before and a few minutes after drug injection and two, four, and eight hours after surgery. The results showed a significant reversal of mydriasis by intraocular dapiprazole, especially with the 0.25% and 0.5% concentrations which did not differ significantly in effectiveness and safety.
ISSN:0886-3350
1873-4502
DOI:10.1016/S0886-3350(13)80411-7