Relationship between TLR4 signalling alterations and effective human cytomegalovirus infection

Toll-like receptors (TLR), the main class of immune-sensor molecules triggering the innate immunity pathways, are known to be involved in the infection of different RNA and DNA viruses, including herpesviruses. Human cytomegalovirus (HCMV) is a widespread human beta-herpesvirus that infects 80–90 %...

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Bibliographic Details
Published inBiopolimery i kletka Vol. 30; no. 5; pp. 329 - 334
Main Authors Germini, D., Arcangeletti, M. C.
Format Journal Article
LanguageEnglish
Published Kiev Natsional'na Akademiya Nauk Ukrainy - National Academy of Sciences of Ukraine 2014
Subjects
Congenital defects
Congenital infection
Cytomegalovirus
DNA viruses
Immunocompromised hosts
Infections
Innate immunity
Ribonucleic acid
RNA
RNA viruses
Signal transduction
TLR4 protein
Toll-like receptors
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Summary:Toll-like receptors (TLR), the main class of immune-sensor molecules triggering the innate immunity pathways, are known to be involved in the infection of different RNA and DNA viruses, including herpesviruses. Human cytomegalovirus (HCMV) is a widespread human beta-herpesvirus that infects 80–90 % of the world’s population and it can cause severe and even fatal diseases in immunocompromised patients and it is also responsible for birth defects as a consequence of congenital infection. Aim of this review is to discuss the existing data regarding the role of TLRs in HCMV concentrating mainly on TLR4. A better understanding in this relationship could be exploited for the development of efficient early diagnosis methodologies and anti viral therapies.
ISSN:0233-7657
1993-6842
DOI:10.7124/bc.0008AE