Regional specificity of relroviral integration

The long-help general opinion was that retroviral integration into the cellular genome occurs at random and it is not clear how the local features of integration can be account for the pattern of integration over the whole genome. Using the compositional approach it was shown that viral integration...

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Bibliographic Details
Published inBiopolimery i kletka Vol. 14; no. 4; pp. 286 - 297
Main Authors Rynditch, A. V., Zoubak, S. V., Tsyba, L. O., Guley, N., Lazurkevitch, Z. V., Bernardi, G.
Format Journal Article
LanguageEnglish
Published Kiev Natsional'na Akademiya Nauk Ukrainy - National Academy of Sciences of Ukraine 1998
Subjects
Chromatin
CpG islands
Gene therapy
Genomes
Integration
Localization
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Summary:The long-help general opinion was that retroviral integration into the cellular genome occurs at random and it is not clear how the local features of integration can be account for the pattern of integration over the whole genome. Using the compositional approach it was shown that viral integration takes place in some regions of the host genome which show a compositional match with viral sequences This regional specificity of retroviral integration has been demonstrated by: (i) our experimental localization of a number of viral sequences integrated in different compositional genomic compartments; (ii) results from other laboratories concerning the localization of retroviral sequences in open chromatin regions and/or next to CpG islands; (Hi) our compositional analysis of genes in the neihgborhood of integrated viral sequences. Such conclusion have, implications concerning the compositional evolution of retroviral genomes and gene therapy.
ISSN:0233-7657
1993-6842
DOI:10.7124/bc.0004DA