MHRT expression during remote ischemic preconditioning in patients with coronary artery disease

• Published in: Biopolimery i kletka Vol. 37; no. 4; pp. 270 - 277
• Main Authors: Khetsuriani, M., Ioffe, N. O., Drevytska, T. I., Niekrasova, V. O., Dosenko, V. E.
• Format: Journal Article
• Language: English
• Published: Kiev Natsional'na Akademiya Nauk Ukrainy - National Academy of Sciences of Ukraine 2021
• Subjects: Blood flow; Blood pressure; Cardiovascular disease; Coronary artery; Coronary vessels; Heart; Heart diseases; Heart surgery; Ischemia; Myocardium; Patients; Polymerase chain reaction; Vein & artery diseases
• ISSN: 0233-7657; 1993-6842
• DOI: 10.7124/bc.000A59

Aim. To access the effect of remote ischemic preconditioning (RIPC) on hemodynamic parameters and expression of lncRNA MHRT in patients with coronary artery disease during isolated coronary artery bypass graft surgery. Methods. The hemodynamic parameters of 29 patients with sham and RIPC procedures were analyzed. RIPC was modulated by three cycles of blocking blood flow in the arm for 5 minutes followed by restoring it for another 5 minutes. Expression of MHRT was measured in myocardial tissue and plasma by real-time polymerase chain reaction. Results. Hemodynamic parameters of patients in the RIPC-group had higher (p < 0.05) values of cardiac index, systolic blood pressure, diastolic blood pressure, stroke volume index compared to the sham group. Systemic vascular resistance index decreased in RIPC-group. The expression level of MHRT in the myocardium was 2.5 times lower than in the sham group (p<0.05). MHRT expression in plasma fall[s] significantly, by more 15 times, (p < 0.0001) in the RIPC-group. Conclusions. A decrease in MHRT expression can be a consequence of the protective effect of RIPC and can be used as a cardiac biomarker.