Postresuscitative Myocardial Impact of Anatoxin Preimmunization

• Published in: Obshchai͡a︡ reanimatologii͡a Vol. 3; no. 6; pp. 103 - 108
• Main Authors: Yenikeyev, D. A., Chizhikov, A. V., Aleksandrov, M. A., Nurgaleyeva, Ye. A., Novgorodova, N. V.
• Format: Journal Article
• Language: English
• Published: Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia 20.12.2007
• Subjects: acute blood loss; diphtheria anatoxin; myocardium; resuscitation; staphylococcal anatoxin; tetanus anatoxin
• ISSN: 1813-9779; 2411-7110
• DOI: 10.15360/1813-9779-2007-6-103-108

Objective: to study the impact of preimmunization with tetanus, diphtheria, and staphylococcal anatoxins on postresuscitative myocardial pathology.Materials and methods. Chronic (5-week) experiments were made on 51 mongrel dogs immunized with tetanus, diphtheria, and staphylococcal anatoxins. Acute one-stage blood loss served as a model of dying. The dogs were resuscitated using autoblood by the complex procedure described by V. A. Negovsky et al. Monitoring (electrophysiological studies of the myocardium and thermodilution) was performed in the postresuscitative period. A morphological study and electron microscopy were made.Results. The authors revealed the stimulating effect of tetanus ana-toxin on the cardiovascular system, the best survival after resuscitation, with less pronounced myocardial dystrophic changes; depressed cardiac performance after immunization with diphtheria anatoxin, significant morphological changes lowering postresuscitative animal survival; deteriorated sinoatrial conduction, transient myocardial dystrophic and necrobiotic changets after immunization with staphylococcal anatoxin.Conclusion. Preimmunization with tetanus ana-toxin has a myocardial stimulating impact in the postresuscitative period, improves animal survival; immunization with diphtheria anatoxin deteriorates the recovery of cardiac performance, and negatively affects postresuscitative survival; immunization with staphylococcal anatoxin causes transient myocardial pathomorphological changes, without negatively affecting the survival rates after resuscitation.