Differentiation of Human IgM Subclasses by the Ability to Interact with a Factor Resembling the First Component of Complement

Abstract Two groups of human IgM proteins are described. One group interacts with a heat-labile component of rabbit or human serum which has characteristics similar to C′1q. The second group fails to interact with this factor. This grouping is not related to κ or λ chains or to previously described...

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Bibliographic Details
Published inThe Journal of immunology (1950) Vol. 103; no. 3; pp. 608 - 612
Main Authors Mackenzie, Malcolm R, Warner, Noel L, Linscott, William D, Fudenberg, H. Hugh
Format Journal Article
LanguageEnglish
Published Am Assoc Immnol 01.09.1969
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Summary:Abstract Two groups of human IgM proteins are described. One group interacts with a heat-labile component of rabbit or human serum which has characteristics similar to C′1q. The second group fails to interact with this factor. This grouping is not related to κ or λ chains or to previously described differences in human IgM molecules. Such a division may provide a tool for the identification of µ chain genetic markers.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.103.3.608