Local and generalized bone loss in rheumatoid arthritis

The article presents a review of cross-sectional studies and long-term prospective observations dedicated to changes in bone mineral density (BMD) in patients with rheumatoid arthritis (RA) and factors influencing it. The relationship between local bone loss (erosion count) and generalized BMD loss...

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Bibliographic Details
Published inSovremennai͡a︡ revmatologii͡a Vol. 15; no. 5; pp. 103 - 107
Main Authors Kovalenko, P. S., Kolganova, N. I., Dydykina, I. S., Kozhevnikova, P. O., Blank, M. Yu
Format Journal Article
LanguageEnglish
Russian
Published IMA-PRESS LLC 20.10.2021
Subjects
bone erosion
bone mineral density
dynamics of bone loss
osteoporosis
resorption
rheumatoid arthritis
x-ray densitometry
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Summary:The article presents a review of cross-sectional studies and long-term prospective observations dedicated to changes in bone mineral density (BMD) in patients with rheumatoid arthritis (RA) and factors influencing it. The relationship between local bone loss (erosion count) and generalized BMD loss was noted. It is indicated that existing RA treatment strategies are aimed at suppressing inflammation rather than preventing bone resorption. There is evidence that anti-inflammatory therapy using glucocorticoids, methotrexate, and biologic DMARDs in combination with antiresorptive drugs (bisphosphonates and denosumab) helps prevent BMD loss and the progression of erosions. It is emphasized that osteoporosis in RA, which belongs to the immune-mediated secondary osteopathies, is one of the most frequent and serious complications of RA, which determine the unfavorable course and prognosis of the underlying disease.
ISSN:1996-7012
2310-158X
DOI:10.14412/1996-7012-2021-5-103-107