Influence of ion interactions on the conformation of ribozyme specific to HIV-1 tat-RNA in solution

Using the method of partial nudease hydrolysis it was shown that the medium ion composition essentially influenced tertiary interactions in the ribozyme molecule and changed its spatial structure.

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Bibliographic Details
Published inBiopolimery i kletka Vol. 18; no. 5; pp. 452 - 454
Main Authors Markelova, O. Yu, Buryanovsky, L. N., Kitam, O. E., Krasnova, K. F., Shved, A. D.
Format Journal Article
LanguageEnglish
Published Kiev Natsional'na Akademiya Nauk Ukrainy - National Academy of Sciences of Ukraine 2002
Subjects
Conformation
HIV
Human immunodeficiency virus
Ribonucleic acid
RNA
Tat protein
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Summary:Using the method of partial nudease hydrolysis it was shown that the medium ion composition essentially influenced tertiary interactions in the ribozyme molecule and changed its spatial structure.
ISSN:0233-7657
1993-6842
DOI:10.7124/bc.000627