The phenomenon of viral chromosomal integration

The literature review is devoted to the chromosomally integrating viruses, the integration property. These are revealed using modern diagnostic methods, including highthroughput sequencing. The review describes various types of viruses, such as retroviruses, adenoviruses, herpes viruses, papillomavi...

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Bibliographic Details
Published inZhurnal infektologii Vol. 16; no. 3; pp. 5 - 16
Main Authors Goleva, O. V., Cherkasova, P. V., Baziian, E. V., Igolkina, A. A., Ejsmont, Yu. A., Skripchenko, N. V., Chukhlovin, A. B., Glotov, O. S.
Format Journal Article
LanguageEnglish
Russian
Published Journal Infectology 20.09.2024
Subjects
chromosomal integration
diagnostics
mechanisms
viruses
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Summary:The literature review is devoted to the chromosomally integrating viruses, the integration property. These are revealed using modern diagnostic methods, including highthroughput sequencing. The review describes various types of viruses, such as retroviruses, adenoviruses, herpes viruses, papillomaviruses, hepatitis B, SARS-CoV-2 and others. These viruses have the ability to integrate their genomes into the host cell genomes and their prevalence. Modern information on the molecular mechanisms of viral integration and methods of differential diagnostics is presented. Each of these viruses has its own unique ways of interacting with the host cell genome to maintain a latent state, which determines the specifics of the infectious process and pathological consequences for the body due to the possibility of effective reactivation.
ISSN:2072-6732
DOI:10.22625/2072-6732-2024-16-3-5-16