Role of molecular mimicry in detection of HIV infection

This review deals with a role of molecular mimicry in detection of the infection caused by the human immunodeficiency virus (HIV). The molecular mimicry is determined as the presence of either similar or completely identical primary amino acid sequence in proteins of different origin. Some HIV prote...

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Bibliographic Details
Published inBiopolimery i kletka Vol. 21; no. 2; pp. 134 - 139
Main Authors Ivanskaya, N. V., Rybalko, S. L.
Format Journal Article
LanguageEnglish
Published Kiev Natsional'na Akademiya Nauk Ukrainy - National Academy of Sciences of Ukraine 2005
Subjects
Amino acid sequence
HIV
Human immunodeficiency virus
Mimicry
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Summary:This review deals with a role of molecular mimicry in detection of the infection caused by the human immunodeficiency virus (HIV). The molecular mimicry is determined as the presence of either similar or completely identical primary amino acid sequence in proteins of different origin. Some HIV protein sequences are shown to be identical with several host ones, so the organism synthesizes antibodies interacting with its own structures; such situation may be a cause of false-positive results of sera testing by serological assays.
ISSN:0233-7657
1993-6842
DOI:10.7124/bc.0006E3