Cellular microenvironment as an object of targeted therapy for malignant neoplasms

The dynamic relationships between tumor cells and their microenvironment are of crucial importance in the development and progression of the malignant process. Given the multifunctional potential of heterogeneous populations surrounding a tumor, targeting components of the microenvironment has long...

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Published inUspehi molekulârnoj onkologii Vol. 10; no. 4; pp. 8 - 20
Main Authors Zyablitskaya, E. Yu, Kubyshkin, A. V., Sorokina, L.  E., Serebryakova, A. V., Aliev, K.  A., Maksimova, P.  E. , Lazarev, A. E., Balakchina, A. I. , Golovkin, I. O. 
Format Journal Article
LanguageEnglish
Russian
Published ABV-press 14.12.2023
Subjects
anticancer therapy
malignant neoplasms
tumor microenvironment
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Summary:The dynamic relationships between tumor cells and their microenvironment are of crucial importance in the development and progression of the malignant process. Given the multifunctional potential of heterogeneous populations surrounding a tumor, targeting components of the microenvironment has long been regarded as a promising strategy in modern anticancer therapy. This review discusses the role of the components of the cellular microenvironment in carcinogenesis, analyzes in detail the main ways and mechanisms of action on the main cell populations, which are of the greatest interest in the context of the development of innovative anticancer therapy.
ISSN:2313-805X
2413-3787
DOI:10.17650/2313-805X-2023-10-4-8-20