Peroxisome Proliferator-Activated Receptor- Is a Potent Target for Prevention and Treatment in Human Prostate and Testicular Cancer

Peroxisome proliferator-activated receptor- (PPAR)- is a ligand-activated transcriptional factor belonging to steroid receptor superfamily. PPAR- plays a role in both adipocyte differentiation and tumorigenesis. Up to date, PPAR- is expressed in various cancer tissues, and PPAR- ligand induces growt...

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Bibliographic Details
Published inPPAR research Vol. 2008; pp. 1 - 12
Main Authors Matsuyama, Masahide, Yoshimura, Rikio
Format Journal Article
LanguageEnglish
Published New York Hindawi Limited 2008
Wiley
Subjects
Cancer therapies
Prostate cancer
Proteins
Rodents
Testicular cancer
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Summary:Peroxisome proliferator-activated receptor- (PPAR)- is a ligand-activated transcriptional factor belonging to steroid receptor superfamily. PPAR- plays a role in both adipocyte differentiation and tumorigenesis. Up to date, PPAR- is expressed in various cancer tissues, and PPAR- ligand induces growth arrest of these cancer cells. In this study, we examined the expression of PPAR- in prostate cancer (PC) and testicular cancer (TC) by RT-PCR and immunohistochemistry, and we also examined the effect of PPAR- ligand in these cells by MTT assay, hoechest staining, and flow cytometry. PPAR- expression was significantly more extensive and intense in malignant tissues than in normal tissues. PPAR- ligand induced the reduction of malignant cell viability through apoptosis. These results demonstrated that the generated PPAR- in PC and TC cells might play an important role in the tumorigenesis. PPAR- may become a new target in the treatment of PC and TC.
ISSN:1687-4757
1687-4765
DOI:10.1155/2008/249849