68Ga-DOTATATE PET/CT in recurrent medullary thyroid carcinoma: a lesion-by-lesion comparison with 111In-octreotide SPECT/CT and conventional imaging
Purpose The aim of this study was to prospectively compare the detection rate of 68 Ga-DOTATATE PET-CT with 111 In-octreotide SPECT-CT and conventional imaging (CI) in medullary thyroid carcinoma (MTC) patients with increased calcitonin (Ctn) levels but negative CI after thyroidectomy. Methods Fifte...
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Published in | European journal of nuclear medicine and molecular imaging Vol. 44; no. 10; pp. 1695 - 1701 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.09.2017
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Subjects | |
Online Access | Get full text |
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Summary: | Purpose
The aim of this study was to prospectively compare the detection rate of
68
Ga-DOTATATE PET-CT with
111
In-octreotide SPECT-CT and conventional imaging (CI) in medullary thyroid carcinoma (MTC) patients with increased calcitonin (Ctn) levels but negative CI after thyroidectomy.
Methods
Fifteen patients with raised Ctn levels and/or CI evidence of recurrence underwent
68
Ga-DOTATATE PET-CT,
111
In-octreotide SPECT-CT and CI. Histopathology, CI and biochemical/clinical/imaging follow-up were used as the reference standard. PET/CT, SPECT/CT and CI were compared in a lesion-based and organ-based analysis.
Results
PET/CT evidenced recurrence in 14 of 15 patients. There were 13 true positive (TP), 1 true negative (TN), 1 false positive (FP) and no false negative (FN) cases, resulting in a sensitivity and accuracy of 100% and 93%. SPECT/CT was positive in 6 of 15 cases. There were 6 TP, 2 TN, 7 FN and no FP cases, resulting in a sensitivity of 46% and accuracy of 53%. CI procedures detected tumor lesions in 14 of 15 patients. There were 13 TP, 1TN, 1 FP and no FN cases with a sensitivity of 100% and accuracy of 93%.
A significantly higher number of lesions was detected by PET/CT (112 lesions,
p
= 0.005) and CI (109 lesions,
p
= 0.005) in comparison to SPECT/CT (16 lesions). There was no significant difference between PET/CT and CI for the total number of detected lesions (
p
= 0.734). PET/CT detected more lesions than SPECT/CT regardless of the organ. PET/CT detected more bone lesions but missed some neck nodal metastases evidenced by CI. The number of lesions per region demonstrated by PET/CT and CI were similar in the other sites.
Conclusion
68
Ga-DOTATATE PET/CT is superior to
111
In-octreotide SPECT/CT for the detection of recurrent MTC demonstrating a significantly higher number of lesions.
68
Ga-DOTATATE PET/CT showed a superior detection rate compared to CI in demonstrating bone metastases. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 1619-7070 1619-7089 |
DOI: | 10.1007/s00259-017-3701-9 |