Absence of mutation in miR-34a gene in a Chinese longevity population

DEAR EDITOR Centenarians are a typical longevity model characterized by delayed onset of morbidity in age-related diseases such as cancer, cardiovascular disease, dementia, and stroke （Andersen et al, 2012）. Though there may be a number of underlying mechanisms behind this longevity, curiously it se...

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Published inDōngwùxué yánjiū Vol. 36; no. 2; pp. 112 - 114
Main Authors Wu, Huan, He, Yong-Han, Xu, Tian-Rui, Kong, Qing-Peng
Format Journal Article
LanguageEnglish
Published China Kunming Institute of Zoology, The Chinese Academy of Sciences 18.03.2015
Subjects
Aged, 80 and over
Asian Continental Ancestry Group
Case-Control Studies
Humans
Longevity - genetics
MicroRNAs - genetics
MicroRNAs - metabolism
Middle Aged
Mutation
Polymorphism, Single Nucleotide
中国人群
人类长寿
基因突变
寿命模型
年龄相关
心血管疾病
老年痴呆症
遗传因子
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Summary:DEAR EDITOR Centenarians are a typical longevity model characterized by delayed onset of morbidity in age-related diseases such as cancer, cardiovascular disease, dementia, and stroke （Andersen et al, 2012）. Though there may be a number of underlying mechanisms behind this longevity, curiously it seems that the survival advantage persists in their offspring （Terry et al, 2003）, suggesting a potentially important role for genetic factors. Previous studies suggested that the heritability of human longevity may be ~25% （Herskind et al, 1996; Mcgue et al, 1993）, whicih is consistent with other studies on model organisms that identified several longevity-related genes, such as age-l, daf-2, daf-16, and sir-2 （Friedman ＆ Johnson, 1988; Kenyon et al, 1993; Lin et al, 1997; Tissenbaum ＆ Guarente, 2001）. Likewise, several studies have reported the existence of many mutations related to human longevity （Holstege et al, 2014; Sebastiani et al, 2012）.
Bibliography:53-1040/Q
DEAR EDITOR Centenarians are a typical longevity model characterized by delayed onset of morbidity in age-related diseases such as cancer, cardiovascular disease, dementia, and stroke （Andersen et al, 2012）. Though there may be a number of underlying mechanisms behind this longevity, curiously it seems that the survival advantage persists in their offspring （Terry et al, 2003）, suggesting a potentially important role for genetic factors. Previous studies suggested that the heritability of human longevity may be ~25% （Herskind et al, 1996; Mcgue et al, 1993）, whicih is consistent with other studies on model organisms that identified several longevity-related genes, such as age-l, daf-2, daf-16, and sir-2 （Friedman ＆ Johnson, 1988; Kenyon et al, 1993; Lin et al, 1997; Tissenbaum ＆ Guarente, 2001）. Likewise, several studies have reported the existence of many mutations related to human longevity （Holstege et al, 2014; Sebastiani et al, 2012）.
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ISSN:0254-5853
DOI:10.13918/j.issn.2095-8137.2015.2.112