Synthesis of a 188Re–DTPMP complex using carrier-free 188Re and study of its stability

Labeling of diethylenetriamine-N,N,N′,N″,N″-pentakis(methylenephosphonic) acid (DTPMP) with rhenium-188 using stannous chloride as a reducing agent has been investigated. Dependence of the yield of the 188 Re–DTPMP complex on the concentration of the reducing agent, pH, reaction time, temperature, a...

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Published inJournal of radioanalytical and nuclear chemistry Vol. 287; no. 3; pp. 779 - 785
Main Authors Nassar, M. Y., El-Kolaly, M. T., Mahran, M. R. H.
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.03.2011
Subjects
Carriers
Chemistry
Chemistry and Materials Science
Diagnostic Radiology
Hadrons
Heavy Ions
Inorganic Chemistry
Marking
Nuclear Chemistry
Nuclear Physics
Optimization
Physical Chemistry
Reducing agents
Saline
Stability
Stability
Rhenium-188
Bone uptake
Biodistribution
DTPMP
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Summary:Labeling of diethylenetriamine-N,N,N′,N″,N″-pentakis(methylenephosphonic) acid (DTPMP) with rhenium-188 using stannous chloride as a reducing agent has been investigated. Dependence of the yield of the 188 Re–DTPMP complex on the concentration of the reducing agent, pH, reaction time, temperature, ascorbic acid and amount of carrier added has been studied. Under optimum conditions, the labeling yield of 188 Re–DTPMP complex is 95% for the carrier-free 188 Re but with the carrier-added 188 Re the labeling yield is more than 97%. Furthermore, the stability of the 188 Re–DTPMP complex against pH change and dilution with saline has been also studied. It is found that the addition of carrier stabilizes the 188 Re–DTPMP complex against pH change and dilution.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-010-0933-6