Efficacy of Herbal Medicine as an Adjunctive Therapy of Chemotherapy for Cervical Cancer: A Systematic Review and Meta-analysis

This study aimed to evaluate the efficacy of herbal medicine (HM) combined with chemotherapy (CT) for cervical cancer. Ten electronic databases including Pubmed, Cochrane library, Embase, Korean databases, and Chinese medical databases were systematically searched up to October 2019. All randomized...

Full description

Saved in:
Bibliographic Details
Published inJournal of Physiology & Pathology in Korean Medicine Vol. 34; no. 5; pp. 255 - 262
Main Authors Oh, Seung Yun, Kim, Mi Suk, Joo, Jong Cheon, Song, Yung Sun
Format Journal Article
LanguageEnglish
Published 한의병리학회 25.10.2020
Subjects
한의학
Herbal medicine
Systematic review
Chemotherapy
Cervical cancer
Meta-analysis
Online AccessGet full text
ISSN1738-7698
2288-2529
DOI10.15188/kjopp.2020.10.34.5.255

Cover

Abstract This study aimed to evaluate the efficacy of herbal medicine (HM) combined with chemotherapy (CT) for cervical cancer. Ten electronic databases including Pubmed, Cochrane library, Embase, Korean databases, and Chinese medical databases were systematically searched up to October 2019. All randomized controlled trials with HM combined with CT to treat cervical cancer were included. A total of 21 trials were included for analysis. Compared to the control group, HM combined with CT group significantly increased tumor response (complete and partial response) (risk ratio [RR] = 1.24, 95% CI: 1.15–1.33, p < 0.00001) and Karnofsky performance score (standardized mean difference [SMD] = 1.71, 95% CI: 1.41–2.01, p < 0.00001). Also, HM combined with CT group remarkably reduced CT toxicity. In Conclusion, our study suggests that HM might be a potential option for cervical cancer to enhance curative efficacy and reduce CT toxicity. KCI Citation Count: 0
AbstractList This study aimed to evaluate the efficacy of herbal medicine (HM) combined with chemotherapy (CT) for cervical cancer. Ten electronic databases including Pubmed, Cochrane library, Embase, Korean databases, and Chinese medical databases were systematically searched up to October 2019. All randomized controlled trials with HM combined with CT to treat cervical cancer were included. A total of 21 trials were included for analysis. Compared to the control group, HM combined with CT group significantly increased tumor response (complete and partial response) (risk ratio [RR] = 1.24, 95% CI: 1.15–1.33, p < 0.00001) and Karnofsky performance score (standardized mean difference [SMD] = 1.71, 95% CI: 1.41–2.01, p < 0.00001). Also, HM combined with CT group remarkably reduced CT toxicity. In Conclusion, our study suggests that HM might be a potential option for cervical cancer to enhance curative efficacy and reduce CT toxicity. KCI Citation Count: 0
Author Mi Suk Kim
Yung Sun Song
Jong Cheon Joo
Seung Yun Oh
Author_xml – sequence: 1
  givenname: Seung Yun
  surname: Oh
  fullname: Oh, Seung Yun
– sequence: 2
  givenname: Mi Suk
  surname: Kim
  fullname: Kim, Mi Suk
– sequence: 3
  givenname: Jong Cheon
  surname: Joo
  fullname: Joo, Jong Cheon
– sequence: 4
  givenname: Yung Sun
  surname: Song
  fullname: Song, Yung Sun
BackLink https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002639078$$DAccess content in National Research Foundation of Korea (NRF)
BookMark eNqNkU9PGzEQxa2KSk2Bz1Bfeuhht_67tiv1EC1pQYIiQThbXq9dTDbryF5S5dSvXidEHHriNJrR-z3NvPkITsY4OgA-YVRjjqX8unqKm01NECkDVFNW85pw_g7MCJGyIpyoEzDDgspKNEp-AOc5hw5xSvctnYG_C--DNXYHo4eXLnVmgDeuDzaMDpoMzQjn_dPzaKewdXD56JLZHLTto1vH6dj7mGDr0rY4DbA1o3XpG5zD-12e3NpMwcI7tw3uT7Hri_1kKjOaYZdDPgPvvRmyOz_WU_DwY7FsL6vr259X7fy6srhpaMU7IX1nObaE9pJ4qgRFljGnFKcd7wkWiveKeysEkkxYwlXTW0dY10tDBD0FX158x-T1ygYdTTjU31Gvkp7fLa-04oqyhhft9xetTTHn5Ly2YSpXxHFKJgwaI30IXx_C1_vw9zPKNNcl_MKL__hNCmuTdm8gPx-3fC5EeYN5RX_dXiwwYgopRuk_PvaZ4g
CitedBy_id crossref_primary_10_1186_s12889_024_18634_3
crossref_primary_10_1177_1934578X211004304
crossref_primary_10_22246_jikm_2022_43_4_751
Cites_doi 10.1007/s00520-015-2737-2
10.1016/j.cellimm.2011.07.011
10.1159/000492641
10.1177/1534735419861693
10.1155/2019/9206951
10.1016/S2214-109X(19)30482-6
10.4103/0253-7613.91872
10.18632/oncotarget.17466
10.1158/1055-9965.EPI-15-0578
10.3389/fphar.2015.00209
10.2147/DDDT.S134518
10.1016/S0140-6736(18)32470-X
10.1200/JCO.2008.16.4368
10.3389/fonc.2019.00730
10.2147/OTT.S219623
10.1038/srep18111
ContentType Journal Article
DBID DBRKI
TDB
AAYXX
CITATION
ACYCR
DOI 10.15188/kjopp.2020.10.34.5.255
DatabaseName DBPIA - 디비피아
Nurimedia DBPIA Journals
CrossRef
Korean Citation Index
DatabaseTitle CrossRef
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
EISSN 2288-2529
EndPage 262
ExternalDocumentID oai_kci_go_kr_ARTI_9593465
10_15188_kjopp_2020_10_34_5_255
NODE10490943
GroupedDBID .UV
ALMA_UNASSIGNED_HOLDINGS
DBRKI
TDB
AAYXX
CITATION
ACYCR
ID FETCH-LOGICAL-c1663-5b78fbc51c23d82f39730c44e9953b5d21795d95fc770847c2596dce24bd8a273
ISSN 1738-7698
IngestDate Sun Mar 09 07:52:02 EDT 2025
Tue Jul 01 02:30:12 EDT 2025
Thu Apr 24 23:08:55 EDT 2025
Thu Feb 06 13:34:55 EST 2025
IsPeerReviewed false
IsScholarly true
Issue 5
Keywords Herbal medicine
Systematic review
Chemotherapy
Cervical cancer
Meta-analysis
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c1663-5b78fbc51c23d82f39730c44e9953b5d21795d95fc770847c2596dce24bd8a273
Notes https://kmpath.jams.or.kr
PageCount 8
ParticipantIDs nrf_kci_oai_kci_go_kr_ARTI_9593465
crossref_citationtrail_10_15188_kjopp_2020_10_34_5_255
crossref_primary_10_15188_kjopp_2020_10_34_5_255
nurimedia_primary_NODE10490943
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2020-10-25
PublicationDateYYYYMMDD 2020-10-25
PublicationDate_xml – month: 10
  year: 2020
  text: 2020-10-25
  day: 25
PublicationDecade 2020
PublicationTitle Journal of Physiology & Pathology in Korean Medicine
PublicationYear 2020
Publisher 한의병리학회
Publisher_xml – name: 한의병리학회
References 10.15188/kjopp.2020.10.34.5.255_ref19
10.15188/kjopp.2020.10.34.5.255_ref17
10.15188/kjopp.2020.10.34.5.255_ref18
10.15188/kjopp.2020.10.34.5.255_ref15
10.15188/kjopp.2020.10.34.5.255_ref37
10.15188/kjopp.2020.10.34.5.255_ref16
10.15188/kjopp.2020.10.34.5.255_ref38
10.15188/kjopp.2020.10.34.5.255_ref5
10.15188/kjopp.2020.10.34.5.255_ref13
10.15188/kjopp.2020.10.34.5.255_ref35
10.15188/kjopp.2020.10.34.5.255_ref4
10.15188/kjopp.2020.10.34.5.255_ref14
10.15188/kjopp.2020.10.34.5.255_ref36
10.15188/kjopp.2020.10.34.5.255_ref7
10.15188/kjopp.2020.10.34.5.255_ref11
10.15188/kjopp.2020.10.34.5.255_ref33
10.15188/kjopp.2020.10.34.5.255_ref6
10.15188/kjopp.2020.10.34.5.255_ref12
10.15188/kjopp.2020.10.34.5.255_ref34
10.15188/kjopp.2020.10.34.5.255_ref9
10.15188/kjopp.2020.10.34.5.255_ref31
10.15188/kjopp.2020.10.34.5.255_ref8
10.15188/kjopp.2020.10.34.5.255_ref10
10.15188/kjopp.2020.10.34.5.255_ref32
10.15188/kjopp.2020.10.34.5.255_ref30
10.15188/kjopp.2020.10.34.5.255_ref1
10.15188/kjopp.2020.10.34.5.255_ref3
10.15188/kjopp.2020.10.34.5.255_ref2
10.15188/kjopp.2020.10.34.5.255_ref28
10.15188/kjopp.2020.10.34.5.255_ref29
10.15188/kjopp.2020.10.34.5.255_ref26
10.15188/kjopp.2020.10.34.5.255_ref27
10.15188/kjopp.2020.10.34.5.255_ref24
10.15188/kjopp.2020.10.34.5.255_ref25
10.15188/kjopp.2020.10.34.5.255_ref22
10.15188/kjopp.2020.10.34.5.255_ref23
10.15188/kjopp.2020.10.34.5.255_ref20
10.15188/kjopp.2020.10.34.5.255_ref21
References_xml – ident: 10.15188/kjopp.2020.10.34.5.255_ref23
– ident: 10.15188/kjopp.2020.10.34.5.255_ref8
  doi: 10.1007/s00520-015-2737-2
– ident: 10.15188/kjopp.2020.10.34.5.255_ref35
  doi: 10.1016/j.cellimm.2011.07.011
– ident: 10.15188/kjopp.2020.10.34.5.255_ref33
  doi: 10.1159/000492641
– ident: 10.15188/kjopp.2020.10.34.5.255_ref5
  doi: 10.1177/1534735419861693
– ident: 10.15188/kjopp.2020.10.34.5.255_ref29
– ident: 10.15188/kjopp.2020.10.34.5.255_ref36
  doi: 10.1155/2019/9206951
– ident: 10.15188/kjopp.2020.10.34.5.255_ref21
– ident: 10.15188/kjopp.2020.10.34.5.255_ref27
– ident: 10.15188/kjopp.2020.10.34.5.255_ref1
  doi: 10.1016/S2214-109X(19)30482-6
– ident: 10.15188/kjopp.2020.10.34.5.255_ref25
– ident: 10.15188/kjopp.2020.10.34.5.255_ref34
  doi: 10.4103/0253-7613.91872
– ident: 10.15188/kjopp.2020.10.34.5.255_ref12
– ident: 10.15188/kjopp.2020.10.34.5.255_ref10
– ident: 10.15188/kjopp.2020.10.34.5.255_ref37
  doi: 10.18632/oncotarget.17466
– ident: 10.15188/kjopp.2020.10.34.5.255_ref14
– ident: 10.15188/kjopp.2020.10.34.5.255_ref18
– ident: 10.15188/kjopp.2020.10.34.5.255_ref16
– ident: 10.15188/kjopp.2020.10.34.5.255_ref2
  doi: 10.1158/1055-9965.EPI-15-0578
– ident: 10.15188/kjopp.2020.10.34.5.255_ref38
  doi: 10.3389/fphar.2015.00209
– ident: 10.15188/kjopp.2020.10.34.5.255_ref32
  doi: 10.2147/DDDT.S134518
– ident: 10.15188/kjopp.2020.10.34.5.255_ref3
  doi: 10.1016/S0140-6736(18)32470-X
– ident: 10.15188/kjopp.2020.10.34.5.255_ref28
– ident: 10.15188/kjopp.2020.10.34.5.255_ref26
– ident: 10.15188/kjopp.2020.10.34.5.255_ref4
  doi: 10.1200/JCO.2008.16.4368
– ident: 10.15188/kjopp.2020.10.34.5.255_ref20
– ident: 10.15188/kjopp.2020.10.34.5.255_ref22
– ident: 10.15188/kjopp.2020.10.34.5.255_ref7
  doi: 10.3389/fonc.2019.00730
– ident: 10.15188/kjopp.2020.10.34.5.255_ref24
– ident: 10.15188/kjopp.2020.10.34.5.255_ref11
– ident: 10.15188/kjopp.2020.10.34.5.255_ref9
– ident: 10.15188/kjopp.2020.10.34.5.255_ref31
  doi: 10.2147/OTT.S219623
– ident: 10.15188/kjopp.2020.10.34.5.255_ref17
– ident: 10.15188/kjopp.2020.10.34.5.255_ref30
– ident: 10.15188/kjopp.2020.10.34.5.255_ref6
  doi: 10.1038/srep18111
– ident: 10.15188/kjopp.2020.10.34.5.255_ref13
– ident: 10.15188/kjopp.2020.10.34.5.255_ref19
– ident: 10.15188/kjopp.2020.10.34.5.255_ref15
SSID ssib053376983
ssib025858678
ssib036278577
ssib038076306
ssib008451798
ssib012146151
Score 2.1232984
Snippet This study aimed to evaluate the efficacy of herbal medicine (HM) combined with chemotherapy (CT) for cervical cancer. Ten electronic databases including...
SourceID nrf
crossref
nurimedia
SourceType Open Website
Enrichment Source
Index Database
Publisher
StartPage 255
SubjectTerms 한의학
Title Efficacy of Herbal Medicine as an Adjunctive Therapy of Chemotherapy for Cervical Cancer: A Systematic Review and Meta-analysis
URI https://www.dbpia.co.kr/journal/articleDetail?nodeId=NODE10490943
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002639078
Volume 34
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
ispartofPNX 동의생리병리학회지, 2020, 34(5), , pp.255-262
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELe68QAvCASI8TFZiDxVKWtixw5vWdZpY9r20E4aT1FiJ9CVJVNpX3jhT4e72PmomFTgJXO9OLLufOc7--53hLznmrFCixw4kGmXwRbkykBmbqpVoFPtiSLDG93zi-Dkin265teDwa9e1NJ6lY3Uj3vzSv6Hq9AHfMUs2X_gbPtR6IA28BeewGF4_hWPJ4j_gPXa8TQe6GPzbPGuHOvHgOhG-gY2rjo8aGbwA0z8RX5rM69MvGZcaww8R8BFsDTp6tMO5NnC79dBGfkqdVMLZdI3bZ3JoSOPnTB0JrETHjmhxIb0sQ3_igInirFxCD3jXg-8yetR0IgcGeOoSDiyvUeZ5qCQhp_X5fCyPbs-n4PKWwzP5rddCBAGMHzNK0zHqlplhkOnMHRa2S3annCAOwtbg8mGrtdkM5G4N_3tk-3pdAE6XQSm2PUor_s8D5cSt4ctdiOwp6rz_lW70eoGSdgaCJ7ZPv7YexDaDlbM4qa6QyBUD09GRj4b8VE7fgPY--LyaDLGi9eQ-TvkgSeEiTM4PWsVomQ1oFzze1xXYe-ucT3w9WTQ4bGBMSIk7xKLsZhA4HfX6GDaIx3qpJOGKDbmESf_4f6pb1hsO-USng_LNRafAA3WM8ZmT8hj60XRyIjEUzLIy2fkZyMOtCqoEQfaiANNv9O0pJ04UCsO-G5fHCiIA23EgRpx-Egj2gkDNcIAn9N0Qxiek6vjySw-cW19EVeNwdB2eSZkkSk-Vp6vpVeAae4fKMbyMOR-xjV46yHXIS-UEMAKoTweBlrlHsu0TMHuf0F2y6rMXxJapAcCcY44E5rl4MIHYcpkwdQ4leDhqD0SNDRMlAXfxxow3xJ0wpH4SU38BImPfT5LeALE3yMH7cA7gz-zfcg7YFKyUPMEsePx75cqWSwT8JBPEwQiZwG8tN_ysP1wf0W-2vbCa_KoE9Y3ZHe1XOdvwUBfZfv1Iv4NYszKPQ
linkProvider Flying Publisher
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Efficacy+of+Herbal+Medicine+as+an+Adjunctive+Therapy+of+Chemotherapy+for+Cervical+Cancer%3A+A+Systematic+Review+and+Meta-analysis&rft.jtitle=%EB%8F%99%EC%9D%98%EC%83%9D%EB%A6%AC%EB%B3%91%EB%A6%AC%ED%95%99%ED%9A%8C%EC%A7%80&rft.au=Seung+Yun+Oh&rft.au=Mi+Suk+Kim&rft.au=Jong+Cheon+Joo&rft.au=Yung+Sun+Song&rft.date=2020-10-25&rft.pub=%ED%95%9C%EC%9D%98%EB%B3%91%EB%A6%AC%ED%95%99%ED%9A%8C&rft.issn=1738-7698&rft.eissn=2288-2529&rft.volume=34&rft.issue=5&rft.spage=255&rft.epage=262&rft_id=info:doi/10.15188%2Fkjopp.2020.10.34.5.255&rft.externalDocID=NODE10490943
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1738-7698&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1738-7698&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1738-7698&client=summon