HEPATITIS A. THE FEATURES OF DISEASE COURSE IN ADULTS

• Published in: Wiadomości lekarskie (1960) Vol. 76; no. 12; p. 2572
• Main Authors: Pryimenko, Nataliia, Koval, Tetiana, Kotelevska, Tetiana, Bodnar, Vadym, Syzova, Liudmyla, Marchenko, Olena
• Format: Journal Article
• Language: English
• Published: Poland 2023
• Subjects: Adult; Aged; Cholestasis; Disease Progression; Hepatitis A - epidemiology; Humans; Incidence; Jaundice - diagnosis; Jaundice - epidemiology; Middle Aged; hepatitis A; atypical course; jaundice
• ISSN: 0043-5147
• DOI: 10.36740/WLek202312104

The aim: To analyze the incidence of Hepatitis A in Ukraine and Poltava region and to study the clinical and epidemiological features of the course of Hepatitis A in adult patients. Materials and methods: The course of HA in 96 hospitalized patients was analyzed. The diagnosis of HA was established on the basis of clinical and epide¬miological data and confirmed by the results of laboratory studies (serological and molecular biological). Results: In 2019, in the Poltava region, there was an increase in the incidence of Hepatitis A with a predominance among sick people of working age, among the urban population. This part of people aged from 60 to 75 years old constitutes 9.4%. This study showed that the waterway was the dominant way of HA transmission. The course of the disease in most hospitalized patients was typical and cyclic, with a predominance of a mixed variant of the pre-jaundice period and jaundice. One third of patients survey that they had fever, which persisted with jaundice. Conclusions: The findings of this study indicates that the patients older than 40 years were more likely to have concomitant chronic pathology than younger patients, and Hepatitis A was more severe with the development of prolonged cholestasis, wave-like course and recurrence. In most patients under the age of 40, the course of Hepatitis A was mild, but splenomegaly and severe cytolytic syndrome were more common.