Immunotherapy with grass pollen major allergens

Perennial hyposensitization with a partially purified timothy extract resulted in a statistically significantly higher degree of clinical protection than treatment with the two timothy major allergens (Nos. 19 and 25) and protected better from the second--than during the first grass pollen season. T...

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Bibliographic Details
Published inAllergy (Copenhagen) Vol. 37; no. 6; p. 379
Main Author Osterballe, O
Format Journal Article
LanguageEnglish
Published Denmark 01.08.1982
Subjects
Adult
Airway Obstruction - diagnosis
Airway Obstruction - therapy
Allergens - administration & dosage
Asthma - diagnosis
Asthma - therapy
Conjunctivitis - diagnosis
Conjunctivitis - therapy
Desensitization, Immunologic
Dose-Response Relationship, Immunologic
Female
Humans
Male
Middle Aged
Nasal Mucosa - metabolism
Pollen - immunology
Prednisone - therapeutic use
Prospective Studies
Rhinitis, Allergic, Seasonal - diagnosis
Rhinitis, Allergic, Seasonal - drug therapy
Rhinitis, Allergic, Seasonal - therapy
Sneezing
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Summary:Perennial hyposensitization with a partially purified timothy extract resulted in a statistically significantly higher degree of clinical protection than treatment with the two timothy major allergens (Nos. 19 and 25) and protected better from the second--than during the first grass pollen season. The extracts were standardized biologically and adsorbed to aluminium hydroxide for administration. The therapy had a more beneficial influence on sneezing than on rhinorrhoea and blockage of nasal airways, and an excellent effect on grass pollen asthma was obtained with the partially purified timothy extract. Associated birch pollen allergy was not influenced by hyposensitization with grass pollen.
ISSN:0105-4538
DOI:10.1111/j.1398-9995.1982.tb02316.x