The Cytotoxic Action of Leucocidin from pseudomonas aerugionsa on Human Polymorphonuclear Leucocytes

Institut für Bakteriologie und Immunologie, Fachbereich Veteriärmedizin und Strahlenzentrum, Universität Giessen, D-63 Giessen, Germany ABSTRACT SUMMARY: Human polymorphonuclear leucocytes treated in vitro with leucocidin from Pseudomonas aeruginosa underwent characteristic morphological alterations...

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Bibliographic Details
Published inJournal of general microbiology Vol. 93; no. 2; pp. 303 - 308
Main Authors SCHARMANN, W, JACOB, F, PORSTENDORFER, J
Format Journal Article
LanguageEnglish
Published Soc General Microbiol 01.04.1976
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Summary:Institut für Bakteriologie und Immunologie, Fachbereich Veteriärmedizin und Strahlenzentrum, Universität Giessen, D-63 Giessen, Germany ABSTRACT SUMMARY: Human polymorphonuclear leucocytes treated in vitro with leucocidin from Pseudomonas aeruginosa underwent characteristic morphological alterations as shown by phase-contrast and scanning electron microscopy. Within a few minutes of exposure to leucocidin the granulocytes became round, and protoplasmic extrusions appeared on the cell membrane, were withdrawn again and put out at another point of the cell. The final stage of the leucocidin-treated leucocyte was an enlarged, rounded vesicle with apparently intact plasma membrane. Omission of calcium ions from the diluting buffer caused certain differences in the morphologic appearance of the damaged leucocytes. * Present address: Bundesgesundheitsamt, D-1, Berlin 33, Postfach, Germany.
ISSN:0022-1287
DOI:10.1099/00221287-93-2-303