Mesenchymal stem cell transplantation in a premature infant with octreotide induced fulminant necrotizing enterocolitis

Necrotizing enterocolitis (NEC) continues to cause significant morbidity and mortality in the newborn period. The mortality rate among severe NEC patients requiring surgery is over 50 %. The capacity of mesenchymal stem cells (MSC) for self-replication, differentiation, preventing apoptosis, and red...

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Published inJournal of neonatal nursing : JNN Vol. 28; no. 2; pp. 130 - 133
Main Authors Bozkaya, Davut, Okman, Esin, Yılmaz, Yavuz, Ok Bozkaya, İkbal, Oğuz, Şerife Suna
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.04.2022
Subjects
Mesenchymal stem cells
Necrotizing enterocolitis
Premature infant
Necrotizing enterocolitis
Premature infant
Mesenchymal stem cells
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Summary:Necrotizing enterocolitis (NEC) continues to cause significant morbidity and mortality in the newborn period. The mortality rate among severe NEC patients requiring surgery is over 50 %. The capacity of mesenchymal stem cells (MSC) for self-replication, differentiation, preventing apoptosis, and reducing inflammation has caused an interest for their use in NEC therapy. Here we present an infant treated with human umbilical cord-derived MSC transplantation 30 days after undergoing surgery for extensive fulminant NEC.
ISSN:1355-1841
1878-089X
DOI:10.1016/j.jnn.2021.07.011