Effect of Kang'ai injection on hepatic fibrosis in rats

To investigate the inhibition role of Kang'ai injection (KAI) in rats with hepatic fibrosis. Animal model with liver fibrosis were induced by 0.01% concentration of diethylnitrosamine (DEN). 30 female Wistar rats (160-200 g) were randomly divided into 3 groups: the KAI-DEN group, the DEN group...

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Bibliographic Details
Published inZhongguo zhongyao zazhi Vol. 37; no. 16; p. 2469
Main Authors Xie, Xinmei, Pang, Rui, Zeng, Fanye, Zhang, Hongliang
Format Journal Article
LanguageChinese
Published China 15.08.2012
Subjects
Animals
Drugs, Chinese Herbal - administration & dosage
Female
Humans
Liver - drug effects
Liver - pathology
Liver Cirrhosis - drug therapy
Liver Cirrhosis - pathology
Male
Rats
Rats, Wistar
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Summary:To investigate the inhibition role of Kang'ai injection (KAI) in rats with hepatic fibrosis. Animal model with liver fibrosis were induced by 0.01% concentration of diethylnitrosamine (DEN). 30 female Wistar rats (160-200 g) were randomly divided into 3 groups: the KAI-DEN group, the DEN group and the blank control group. The KAI-DEN group was administered Kang'ai injection (1 mL x k(-1), intraperitoneal injection, once a week) and the DEN group was administered normal saline intraperitoneal injection. HE staining and VG special staining of liver tissue were used to evaluate liver fibrosis. Compared with the DEN group, relatively less structural damage and less pseudolobular formation in the KAI-DEN group. Collagen area of the blank control group, the KAI-DEN group and the DEN group were (6.52 +/- 2.64)% , (17.41 +/- 1.112)% and (20.180 +/- 2.519)% , respectively. The difference was statistically significant, P < 0.05. Kang'ai injection could inhibit the formation of DEN-induced liver fibrosis.
ISSN:1001-5302
DOI:10.4268/cjcmm20121626