Study on preparation and in vitro characteristics of ginsenoside Rg3 binary solid dispersion

With low molecular weight chitosan and poloxamer 188 as the joint carriers, ginsenoside Rg3 solid dispersions were prepared by using the solvent evaporation method for an in vitro dissolution test. Subsequently, differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and X-ray di...

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Published inZhongguo zhongyao zazhi Vol. 38; no. 24; p. 4298
Main Authors Liu, Qi-Yuan, Zhang, Zhen-Hai, Jin, Xin, Yu, Zhao-Hui, Jia, Xiao-Bin
Format Journal Article
LanguageChinese
Published China 15.12.2013
Subjects
Chitosan - chemistry
Drug Compounding - methods
Ginsenosides - chemistry
Molecular Weight
Poloxamer - chemistry
Solvents - chemistry
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Summary:With low molecular weight chitosan and poloxamer 188 as the joint carriers, ginsenoside Rg3 solid dispersions were prepared by using the solvent evaporation method for an in vitro dissolution test. Subsequently, differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and X-ray diffraction (X-RD) were adopted for a phase analysis. The results showed that the 60 min in vitro cumulative dissolution rate of ginsenoside Rg3 solid dispersions prepared with low molecular weight chitosan and poloxamer 188 at the ratio of 2:1 exceeded 90%, and the drug was dispersed in carriers in an amorphous state. Therefore, ginsenoside Rg3 solid dispersions prepared with low molecular weight chitosan and poloxamer 188 could help significantly improve the drug dissolution, with a practical application value.
ISSN:1001-5302
DOI:10.4268/cjcmm20132421