Central neurocytomas of the cervical spinal cord. Report of two cases

Central neurocytoma is a neuronal neoplasm that occurs supratentorially in the lateral or third ventricles. The authors report the clinical, neuroradiological, and neuropathological features of two neurocytomas arising in the spinal cord of two men, aged 65 and 49 years. The patients presented with...

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Bibliographic Details
Published inJournal of neurosurgery Vol. 81; no. 2; p. 288
Main Authors Tatter, S B, Borges, L F, Louis, D N
Format Journal Article
LanguageEnglish
Published United States 01.08.1994
Subjects
Aged
Cell Nucleus - ultrastructure
Cervical Vertebrae
Cytoplasm - ultrastructure
Diagnosis, Differential
Ependymoma - pathology
Glioma - pathology
Humans
Male
Microtubules - ultrastructure
Middle Aged
Neurocytoma - pathology
Oligodendroglioma - pathology
Spinal Cord Neoplasms - pathology
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Summary:Central neurocytoma is a neuronal neoplasm that occurs supratentorially in the lateral or third ventricles. The authors report the clinical, neuroradiological, and neuropathological features of two neurocytomas arising in the spinal cord of two men, aged 65 and 49 years. The patients presented with progressive neurological deficits referable to the cervical spinal cord. Magnetic resonance imaging revealed isodense intramedullary spinal cord tumors at the C3-4 level. Both tumors were initially misdiagnosed as gliomas. In Case 1 the correct diagnosis was made after electron microscopy revealed neuronal features. Immunostaining in Case 2 revealed that tumor cells were positive for synaptophysin and negative for glial fibrillary acidic protein, strongly indicating a neuronal tumor. It is suggested that this spinal cord neoplasm be included under the designation "central neurocytoma."
ISSN:0022-3085
DOI:10.3171/jns.1994.81.2.0288