Ganglion-Specific Splicing of TRPV1 Underlies Infrared Sensation in Vampire Bats

The vampire bat uses this strategy toproduce physiologically distinct channels, thereby generating a hypersensitive detector (TRPV1-S) within a specific thermosensory organ, without sacrificing somatic thermo-sensation and/or thermonociception. [...] our results demonstrate that sequence variation w...

Full description

Saved in:
Bibliographic Details
Published inBiophysical journal Vol. 102; no. 3; p. 24a
Main Authors Gracheva, Elena O., Cordero-Morales, Julio F., González-Carcacóa, José A., Ingolia, Nicholas T., Manno, Manno, Aranguren, Carla I., Weissman, Jonathan S., Julius, David
Format Journal Article
LanguageEnglish
Published London Elsevier Inc 31.01.2012
Nature Publishing Group
Subjects
Amino acids
Bats
Cloning
Genomes
Infrared radiation
Temperature
Online AccessGet full text

Cover

More Information
Summary:The vampire bat uses this strategy toproduce physiologically distinct channels, thereby generating a hypersensitive detector (TRPV1-S) within a specific thermosensory organ, without sacrificing somatic thermo-sensation and/or thermonociception. [...] our results demonstrate that sequence variation within a specific region of the cytoplasmic C-terminus accounts for differential thermal response profiles of vampire bat TRPV1 isoforms.
ISSN:0006-3495
0028-0836
1542-0086
1476-4687
DOI:10.1016/j.bpj.2011.11.157