No evidence of INI1hSNF5 (SMARCB1) and PARVG point mutations in oligodendroglial neoplasms

• Published in: Cancer genetics and cytogenetics Vol. 160; no. 2; pp. 169 - 173
• Main Authors: Alonso, M Eva, Bello, M Josefa, de Campos, Jose M, Isla, Alberto, Vaquero, Jesús, Gutierrez, Manuel, Sarasa, Jose L, Rey, Juan A
• Format: Journal Article
• Language: English
• Published: United States 15.07.2005
• Subjects: Actinin - genetics; Base Sequence; Chromosomal Proteins, Non-Histone; Disease Progression; DNA Mutational Analysis; DNA-Binding Proteins - genetics; Exons - genetics; Genes, Tumor Suppressor; Humans; Introns - genetics; Oligodendroglioma - genetics; Point Mutation - genetics; Polymorphism, Single-Stranded Conformational; SMARCB1 Protein; Transcription Factors
• ISSN: 0165-4608; 1873-4456
• DOI: 10.1016/j.cancergencyto.2004.12.020

Allelic losses of chromosome 22 found in oligodendrogliomas suggest that at least one tumor suppressor gene on chromosome 22 is inactivated during the multistep process of tumorigenesis in this glial tumor. INI1hSNF5 (HUGO symbol: SMARCB1), located at 22q11, encodes a component of the ATP-dependent chromatin remodeling hSWI-SNF complex; it is a tumor suppressor gene that is mutated in several malignant tumors. The PARVG gene, located at 22q13, has been found to exhibit reduced expression in some cancer lines. Both genes are thus candidate tumor suppressors, potentially involved in the pathogenesis of gliomas. We performed mutation analyses of INI1hSNF5 and PARVG in a series of 40 oligodendrogliomas, but only sequence polymorphic variations were identified. Accordingly, INI1hSNF5 and PARVG do not seem to be the tumor suppressor genes involved in oligodendroglioma development and progression.