Serotonergic abnormalities in males with extreme levels of impulsive aggression, investigated using 11C-DASB and 11C-MDL100907 PET
[...]the few molecular PET findings to date are unreplicated or apparently conflicting. 5-HT reuptake transporters (SERT) are reported to be reduced in the anterior cingulate (ACC) [1, 2], and 5-HT2A receptors to be either locally increased in entorhinal cortex [2] or decreased more widely in prefro...
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| Published in | NeuroImage (Orlando, Fla.) Vol. 52; no. S1; p. S45 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier Limited
01.08.2010
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| Subjects | |
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| Abstract | [...]the few molecular PET findings to date are unreplicated or apparently conflicting. 5-HT reuptake transporters (SERT) are reported to be reduced in the anterior cingulate (ACC) [1, 2], and 5-HT2A receptors to be either locally increased in entorhinal cortex [2] or decreased more widely in prefrontal cortex [3]. Across individuals, brainstem SERT BPND was significantly (p<=0.05) positively correlated with IA measures, set-shifting errors, deficient response inhibition, risk-taking, childhood trauma and stressful early life events. |
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| AbstractList | [...]the few molecular PET findings to date are unreplicated or apparently conflicting. 5-HT reuptake transporters (SERT) are reported to be reduced in the anterior cingulate (ACC) [1, 2], and 5-HT2A receptors to be either locally increased in entorhinal cortex [2] or decreased more widely in prefrontal cortex [3]. Across individuals, brainstem SERT BPND was significantly (p<=0.05) positively correlated with IA measures, set-shifting errors, deficient response inhibition, risk-taking, childhood trauma and stressful early life events. |
| Author | Rylands, Angela J Hinz, Rainer Fairclough, Michael E Talbot, Peter S Barnett, Elizabeth Brown, Gavin Jones, Matthew Nolan, Steven McMahon, Adam W |
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| DOI | 10.1016/j.neuroimage.2010.04.226 |
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| Title | Serotonergic abnormalities in males with extreme levels of impulsive aggression, investigated using 11C-DASB and 11C-MDL100907 PET |
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