Serotonergic abnormalities in males with extreme levels of impulsive aggression, investigated using 11C-DASB and 11C-MDL100907 PET

[...]the few molecular PET findings to date are unreplicated or apparently conflicting. 5-HT reuptake transporters (SERT) are reported to be reduced in the anterior cingulate (ACC) [1, 2], and 5-HT2A receptors to be either locally increased in entorhinal cortex [2] or decreased more widely in prefro...

Full description

Saved in:
Bibliographic Details
Published inNeuroImage (Orlando, Fla.) Vol. 52; no. S1; p. S45
Main Authors Rylands, Angela J, Hinz, Rainer, Jones, Matthew, Barnett, Elizabeth, Fairclough, Michael E, Nolan, Steven, Brown, Gavin, McMahon, Adam W, Talbot, Peter S
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Limited 01.08.2010
Subjects
Medical research
Online AccessGet full text

Cover

More Information
Summary:[...]the few molecular PET findings to date are unreplicated or apparently conflicting. 5-HT reuptake transporters (SERT) are reported to be reduced in the anterior cingulate (ACC) [1, 2], and 5-HT2A receptors to be either locally increased in entorhinal cortex [2] or decreased more widely in prefrontal cortex [3]. Across individuals, brainstem SERT BPND was significantly (p<=0.05) positively correlated with IA measures, set-shifting errors, deficient response inhibition, risk-taking, childhood trauma and stressful early life events.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2010.04.226