89Zr as a promising radionuclide and it’s applications for effective cancer imaging

Molecular imaging using PET plays an important role for the diagnosis of different diseases. Immuno-PET combines the utilization of PET radionuclides and antibodies/proteins/peptides, presenting a popular method for imaging of different diseases, including cancer. 89 Zr is an attractive radiometal f...

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Bibliographic Details
Published inJournal of radioanalytical and nuclear chemistry Vol. 330; no. 1; pp. 15 - 28
Main Authors Sarcan, E. Tugce, Silindir-Gunay, Mine, Ozer, A. Yekta, Hartman, Neil
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 2021
Springer Nature B.V
Subjects
Antibodies
Biomolecules
Cancer
Chemistry
Chemistry and Materials Science
Diagnostic Radiology
Hadrons
Heavy Ions
Inorganic Chemistry
Medical imaging
Nuclear Chemistry
Nuclear Physics
Peptides
Physical Chemistry
Positron emission
Proteins
Radiation dosage
Radioisotopes
Tomography
Zirconium isotopes
Zr
Zr radiolabelling
Zr-mAb
immuno-PET
Zr-gold NPs
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Summary:Molecular imaging using PET plays an important role for the diagnosis of different diseases. Immuno-PET combines the utilization of PET radionuclides and antibodies/proteins/peptides, presenting a popular method for imaging of different diseases, including cancer. 89 Zr is an attractive radiometal for immuno-PET but far from ideal due to its high radiation dose for the patients. However, its long half-life is sometimes advantageous and suitable for labelling antibodies, proteins and other biomolecules. This review compiles opportunities and applications for using 89 Zr in preclinical and clinical practice. It contains either results from for its production, preclinical and clinical studies.
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-021-07928-0