Epithelial stress enters the dance in coeliac disease

Coeliac disease is an immune-mediated enteropathy induced by gluten. Generation of gluten-specific CD4 + T cells is necessary but not sufficient to induce overt disease. Now, epithelial stress has been proposed as a distinct factor that synergizes with the anti-gluten adaptive immune response to ind...

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Bibliographic Details
Published inNature reviews. Gastroenterology & hepatology Vol. 12; no. 9; pp. 491 - 492
Main Authors Cerf-Bensussan, Nadine, Meresse, Bertrand
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.09.2015
Nature Publishing Group
Subjects
631/250/2152
692/4020/1503/1581/1357
692/420
Biomedicine
Celiac disease
Gastroenterology
Gluten
Health aspects
Hepatology
Medicine & Public Health
news-and-views
Physiological aspects
Risk factors
T cells
France
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Summary:Coeliac disease is an immune-mediated enteropathy induced by gluten. Generation of gluten-specific CD4 + T cells is necessary but not sufficient to induce overt disease. Now, epithelial stress has been proposed as a distinct factor that synergizes with the anti-gluten adaptive immune response to induce intraepithelial lymphocyte activation and tissue damage.
ISSN:1759-5045
1759-5053
DOI:10.1038/nrgastro.2015.120