Acute fatty liver of pregnancy. A reassessment based on observations in nine patients

Acute fatty liver of pregnancy was diagnosed in nine patients over a 10-year period. Eight patients had severe hepatic dysfunction typical for this syndrome and one had subclinical disease but typical hepatic histologic findings. All patients survived with little fetal wastage; all had preeclampsia....

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Bibliographic Details
Published inAnnals of internal medicine Vol. 106; no. 5; p. 703
Main Authors Riely, C A, Latham, P S, Romero, R, Duffy, T P
Format Journal Article
LanguageEnglish
Published United States 01.05.1987
Subjects
Acute Disease
Adult
Biopsy
Fatty Liver - etiology
Fatty Liver - pathology
Female
Humans
Pre-Eclampsia - complications
Pregnancy
Pregnancy Complications - etiology
Pregnancy Complications - pathology
Pregnancy Trimester, Third
Retrospective Studies
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Summary:Acute fatty liver of pregnancy was diagnosed in nine patients over a 10-year period. Eight patients had severe hepatic dysfunction typical for this syndrome and one had subclinical disease but typical hepatic histologic findings. All patients survived with little fetal wastage; all had preeclampsia. Histologic findings included cholestasis, hepatocellular necrosis, and inflammation, as well as microvesicular fat. Histologic findings from biopsy specimens of four of seven patients were initially misinterpreted as hepatitis. This disorder may have both a broad clinical and histologic spectrum; it is probably not rare but often misdiagnosed, perhaps as viral hepatitis. The concurrence of this disorder with toxemia of pregnancy suggests that these entities may be pathophysiologically related.
ISSN:0003-4819
DOI:10.7326/0003-4819-106-5-703