Amphiphilic networks. VIII: Reduced in vitro thromboresistance of amphiphilic networks

• Published in: Polymer bulletin (Berlin, Germany) Vol. 34; no. 1; pp. 101 - 107
• Main Authors: BLEZER, R, LINDHOUT, T, KESZLER, B, KENNEDY, J. P
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 1995; Berlin; New York, NY
• Subjects: Applied sciences; Biological and medical sciences; Biological properties; Exact sciences and technology; Medical sciences; Organic polymers; Physicochemistry of polymers; Properties and characterization; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Technology. Biomaterials. Equipments. Material. Instrumentation; Biological properties; Human; Blood coagulation; Methacrylate polymer; Activation; Experimental study; Adhesion; Amphiphilic compound; In vitro; Acrylamide derivative polymer; Blood; Hydroxyethyl methacrylate polymer; Interpenetrating network; Isobutene polymer; Platelet function; Biocompatibility; Biomaterial; Coagulation factor
• ISSN: 0170-0839; 1436-2449
• DOI: 10.1007/BF00294894

Platelet adhesion to and blood coagulation activation by amphiphilic networks (i.e., water soluble acrylates crosslinked by hydrophobic polyisobutylene) have been investigated in reference to polyethylene (PE) and poly(vinyl chloride) (PVC) controls in vitro. Among the amphiphilic networks examined, that containing poly(N,N-dimethylacrylamide) exhibited lowest thrombogenicity and showed significantly lower platelet adhesion than PVC, i.e., the reference with the lowest thrombogenicity. The amphiphilic network containing poly(2-dimethylaminoethyl methacrylate) exhibited less thromboresistance as judged by the adherence of a large number of procoagulant platelets. According to these findings precisely tailored amphiphilic networks may give rise to materials with blood compatibility superior to those currently in use.