Standard Multiple Regression Analysis Model for Cell Survival/ Death Decision of JNK Protein Using HT-29 Carcinoma Cells
Signaling by the JNK protein has been studied for more than decades with various previous reviews covering more specific aspects. For estimating the relationship among variables a statistical technique called Regression analysis (RA) is used. RA is used to determine the correlation among two or more...
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Published in | International journal of innovative technology and exploring engineering Vol. 8; no. 10; pp. 187 - 197 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
30.08.2019
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Online Access | Get full text |
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Summary: | Signaling by the JNK protein has been studied for more than decades with various previous reviews covering more specific aspects. For estimating the relationship among variables a statistical technique called Regression analysis (RA) is used. RA is used to determine the correlation among two or more variables. In this paper, a multiple regression analysis is used to assess the most significant contribution of JNK protein using ten different concentrations of TNF, EGF, and Insulin that control the survival/ apoptosis response of HT-29 human colon carcinoma cells. The data is analyzed using Statistica software. Data normality and the outliers were checked by visual method (histograms, box plot and Q-Q plot). Descriptive statistics (mean and standard deviation) and correlation matrix (correlation and covariance between variables) are used to get the best concentration. Standard regression analysis is used to make a model through which analysis of variance, regression coefficient & correlation coefficients were analysed and based on the p-value we come to know that 100-0-500 yields the best concentration level which helps in the analysis the cell survival/ apoptosis of JNK protein that was validated by variable importance plot. |
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ISSN: | 2278-3075 2278-3075 |
DOI: | 10.35940/ijitee.H7163.0881019 |