Production of cytokines by cell-effectors of natural cytotoxicity system in mice under development of Lewis lung carcinoma

• Published in: Bi͡u︡lletenʹ Sibirskoĭ medit͡s︡iny Vol. 3; no. 2; pp. 24 - 29
• Main Authors: Sherstoboyev, Ye. Yu, Kaplya, O. A., Zuyeva, Ye. P., Razina, T. G., Epstein, O. I.
• Format: Journal Article
• Language: English
• Published: Siberian State Medical University (Tomsk) 30.06.2004
• Subjects: карцинома легких льюис; лимфоциты; перитонеальные макрофаги; цитокины
• ISSN: 1682-0363; 1819-3684
• DOI: 10.20538/1682-0363-2004-2-24-29

Cytokine production by cell-effectors of natural cytotoxicity system under Lewis lung carcinoma development in F1(CBAxC57B1/6) line mice has been studied. It has been revealed the increase of interleukin-1β (IL-1β) production and tumor necrosis factor-α (TNF-α) by peritoneal macrophages. At this the balance of cytokines produced by T-helpers (Th)  has  been displaced to Th2 side, IL-4 production has increased and interferon-γ (IFN-γ) and IL-2 production has decreased. The rise of IL-10 production by lymphocytes has been observed in the later terms of tumor development.