Association of cytokines gene polymorphisms (TNF and IL8) with chronic obstructive pulmonary disease development

The association of the tumor necrosis TNF-α –308G/A polymorphism and interleukin-8 genetic IL8 –251А/Т polymorphism with the development of the chronic obstructive lung disease (COLD) in two Tomsk populations (Siberian Tatars and Russians) has been studied. The data on interethnic differences in the...

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Bibliographic Details
Published inBi͡u︡lletenʹ Sibirskoĭ medit͡s︡iny Vol. 9; no. 3; pp. 91 - 97
Main Authors Seitova, G. N., Bukreyeva, Ye. B., Kremis, I. S., Puzyryov, V. P.
Format Journal Article
LanguageEnglish
Published Siberian State Medical University (Tomsk) 28.06.2010
Subjects
ген il8
ген tnf
генетические маркеры
интерлейкин-8
наследственная предрасположенность
полиморфизм
фактор некроза опухолей α
хроническая обструктивная болезнь легких
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Summary:The association of the tumor necrosis TNF-α –308G/A polymorphism and interleukin-8 genetic IL8 –251А/Т polymorphism with the development of the chronic obstructive lung disease (COLD) in two Tomsk populations (Siberian Tatars and Russians) has been studied. The data on interethnic differences in the structure of COLD susceptibility have been obtained. In Siberian Tatars, the TNF –308G allelic variant plays a role in the COLD development. In Russians, no association of the studied genetic markers with COLD was reveled.
ISSN:1682-0363
1819-3684
DOI:10.20538/1682-0363-2010-3-91-97