Features of gouty arthritis and comorbid conditions in it — data from the city register of Saint Petersburg for 2000–2019

• Published in: РМЖ: Медицинское обозрение Vol. 4; no. 8; pp. 475 - 482
• Main Authors: Fonturenko, A.Yu, Bashkinov, R.A., Mazurov, V.I., Gaidukova, I.Z., Petrova, M.S., Inamova, O.V., Shapovalov, A.A., Nagirnyak, I.M.
• Format: Journal Article
• Language: English
• Published: 2020
• ISSN: 2587-6821; 2686-9918
• DOI: 10.32364/2587-6821-2020-4-8-475-482

Aim: To study of the features of the course of gout and the occurrence of comorbid conditions in patients with gouty arthritis for the period from 2000 to 2019.Patients and Methods: Based on data from the Saint Petersburg city register of gout and asymptomatic hyperuricemia for the period from 2000 to 2019, formed on the basis of the GALENOS cloud electronic data storage system (© OOO Techlab), an analysis of the clinical course of gouty arthritis and the prevalence of comorbid conditions was performed.Results: This study includes the results of a survey of 1,725 patients. The average follow-up time for patients was 4.85±3.36 (1–17) years. In the studied patients, chronic forms of gouty arthritis prevailed (exacerbation of chronic arthritis — 1198 (69.45%) patients, the presence of tofuses — in 522 (30.26%) patients. The frequency of comorbid conditions such as: arterial hypertension, acute myocardial infarction, tension angina, pulmonary embolism, cardiomyopathy, chronic heart failure, transient ischemic attack, acute cerebrovascular accident in history, chronic obstructive pulmonary disease, peptic ulcer disease of various localization, chronic pancreatitis, overweight or obesity, type 2 diabetes mellitus, chronic pyelonephritis, urolithiasis and chronic kidney disease significantly exceeded the population (p≤0.05). Elevated uric acid levels were observed in 91.42% of patients with type 2 diabetes, 93.86% with hypertension, 94.33% with nephropathy, 92.93% with urolithiasis, 97.75% with acute myocardial infarction and 93.96% with overweight /obesity. Patients received a wide range of medications for both relieving acute GA and normalizing UA levels, and for the treatment of comorbid conditions.Conclusions: Patients with gouty arthritis have a high incidence of comorbid conditions, greater than in the population, the severity of which directly depends on the increase in the level of uric acid.KEYWORDS: gouty arthritis, gout, tophus, comorbidity, uric acid, hyperuricemia.FOR CITATION: Fonturenko A.Yu., Bashkinov R.A., Mazurov V.I. et al. Features of gouty arthritis and comorbid conditions in it — data from the city register of Saint Petersburg for 2000–2019. Russian Medical Inquiry. 2020;4(8):475–482. DOI: 10.32364/2587-6821-2020-4-8-475-482.