Quantitative evaluation of central-type benzodiazepine receptors with [ 125I] Iomazenil in experimental epileptogenesis
This study aimed at quantitatively evaluating hippocampal central-type benzodiazepine receptors (BZRs) in the kainate model of temporal lobe epilepsy (TLE) by in vitro autoradiography (ARG) using [ 125I] Iomazenil (IMZ) specific ligand for central-type BZRs. Kainate (1 μg/0.5 μl) was injected into t...
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| Published in | Epilepsy research Vol. 61; no. 1; pp. 105 - 112 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier B.V
01.09.2004
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| Abstract | This study aimed at quantitatively evaluating hippocampal central-type benzodiazepine receptors (BZRs) in the kainate model of temporal lobe epilepsy (TLE) by in vitro autoradiography (ARG) using [
125I] Iomazenil (IMZ) specific ligand for central-type BZRs. Kainate (1
μg/0.5
μl) was injected into the left amygdala to induce limbic status epilepticus. One, three, or six months after injection, in vitro ARG with [
125I] IMZ and cell counts were performed in the hippocampal CA1–4 regions and dentate gyrus ipsilateral to the kainate injection site, and were compared with the vehicle-injected control group. In all kainate-treated rats, clear pyramidal neuron loss was observed in left hippocampal areas CA1–4. Compared with the control group, progressive reduction of [
125I] IMZ binding was also observed. This resulted in a marked binding decrease paralleling pyramidal neuron loss in hippocampal areas CA1 (down to 83% of control), CA2 (76%), CA3 (75%), and CA4 (90%) at 6 months after kainate administration. Conversely, [
125I] IMZ binding significantly increased in the dentate gyrus (up to 106% of control) at 1 month, but returned to nearly normal at 3–6 months. These results suggest that central-type BZR neuroimaging is useful in detecting hippocampal sclerosis in the mesial TLE, though central BZR alterations differ depending on hippocampal subfields and post-seizure time-courses. |
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| AbstractList | This study aimed at quantitatively evaluating hippocampal central-type benzodiazepine receptors (BZRs) in the kainate model of temporal lobe epilepsy (TLE) by in vitro autoradiography (ARG) using [
125I] Iomazenil (IMZ) specific ligand for central-type BZRs. Kainate (1
μg/0.5
μl) was injected into the left amygdala to induce limbic status epilepticus. One, three, or six months after injection, in vitro ARG with [
125I] IMZ and cell counts were performed in the hippocampal CA1–4 regions and dentate gyrus ipsilateral to the kainate injection site, and were compared with the vehicle-injected control group. In all kainate-treated rats, clear pyramidal neuron loss was observed in left hippocampal areas CA1–4. Compared with the control group, progressive reduction of [
125I] IMZ binding was also observed. This resulted in a marked binding decrease paralleling pyramidal neuron loss in hippocampal areas CA1 (down to 83% of control), CA2 (76%), CA3 (75%), and CA4 (90%) at 6 months after kainate administration. Conversely, [
125I] IMZ binding significantly increased in the dentate gyrus (up to 106% of control) at 1 month, but returned to nearly normal at 3–6 months. These results suggest that central-type BZR neuroimaging is useful in detecting hippocampal sclerosis in the mesial TLE, though central BZR alterations differ depending on hippocampal subfields and post-seizure time-courses. |
| Author | Hirao, Toru Tamagami, Hiroshi Kakumoto, Miki Morimoto, Kiyoshi Watanabe, Takemi Ninomiya, Takashi Tanaka, Akihiro |
| Author_xml | – sequence: 1 givenname: Hiroshi surname: Tamagami fullname: Tamagami, Hiroshi email: hiroshi_tamagami@nmp.co.jp organization: Research Center, Nihon Medi-Physics Co. Ltd., 3-1 Kitasode, Sodegaura City, Chiba Pref. 299-0266, Japan – sequence: 2 givenname: Kiyoshi surname: Morimoto fullname: Morimoto, Kiyoshi organization: Department of Neuropsychiatry, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan – sequence: 3 givenname: Takemi surname: Watanabe fullname: Watanabe, Takemi organization: Department of Neuropsychiatry, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan – sequence: 4 givenname: Takashi surname: Ninomiya fullname: Ninomiya, Takashi organization: Department of Neuropsychiatry, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan – sequence: 5 givenname: Toru surname: Hirao fullname: Hirao, Toru organization: Department of Neuropsychiatry, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan – sequence: 6 givenname: Akihiro surname: Tanaka fullname: Tanaka, Akihiro organization: Research Center, Nihon Medi-Physics Co. Ltd., 3-1 Kitasode, Sodegaura City, Chiba Pref. 299-0266, Japan – sequence: 7 givenname: Miki surname: Kakumoto fullname: Kakumoto, Miki organization: Research Center, Nihon Medi-Physics Co. Ltd., 3-1 Kitasode, Sodegaura City, Chiba Pref. 299-0266, Japan |
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| Cites_doi | 10.1016/0006-8993(93)91701-S 10.1016/S0306-4522(01)00043-4 10.1212/WNL.43.10.1998 10.1523/JNEUROSCI.22-18-08052.2002 10.1016/0024-3205(90)90182-Q 10.1097/00006231-199107000-00002 10.1038/82900 10.1016/S0140-6736(88)92468-3 10.1093/brain/119.5.1677 10.1212/WNL.54.12.2252 10.1046/j.0022-3042.2002.00769.x 10.1523/JNEUROSCI.23-06-02440.2003 10.1016/0013-4694(93)90186-Y 10.1038/2661 10.1016/0969-8051(93)90082-6 10.1016/S0304-3940(99)00080-4 10.1016/0006-8993(91)90938-R 10.1093/brain/121.11.2067 10.1016/j.pneurobio.2004.03.009 10.1212/WNL.45.5.934 10.1002/(SICI)1096-9861(19970901)385:3<385::AID-CNE4>3.0.CO;2-# 10.1016/0920-1211(90)90085-A 10.1212/WNL.42.4.811 10.1002/hipo.450010106 10.1046/j.1460-9568.2003.02597.x 10.1126/science.8093417 10.1046/j.1528-1157.2002.137601.x 10.1016/S0074-7742(01)45013-6 10.1016/0301-0082(92)90023-8 |
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| Keywords | Temporal lobe epilepsy Kainate model Benzodiazepine receptor Central-type Rat Iomazenil |
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| References | Veenman, Leschiner, Spanier, Weisinger, Weizman, Gavish (bib31) 2002; 80 Matsuda, Matsuda, Morimoto, Torizuka (bib18) 2003; 44 Wu, Leung (bib32) 2001; 104 Brooks-Kayal, Shumate, Jin, Rikhter, Coulter (bib4) 1998; 4 Johnson, Woods, Zoghbi, McBride, Baldwin, Innis (bib11) 1990; 47 Sata, Matsuda, Mihara, Aihara, Yagi, Yonekura (bib26) 2002; 43 Beer, Blauenstein, Hasler, Delaloye, Riccabona, Bangerl, Hunkeler, Bonetti, Pieri, Richards, Schubiger (bib1) 1990; 31 Buckmaster, Dudek (bib5) 1997; 385 Oliva, Lam, Swann (bib21) 2002; 22 Cohen, Lin, Quirk, Coulter (bib7) 2003; 17 Sloviter (bib29) 1991; 1 Burdette, Sakurai, Henry, Ross, Pennell, Frey, Sackellares, Albin (bib6) 1995; 45 Bekenstein, Lothman (bib3) 1993; 259 Savic, Persson, Roland, Pauli, Sedvall, Widen (bib27) 1988; 2 Milgram, Yearwood, Khurgel, Ivy, Racine (bib19) 1991; 551 Cossart, Dinocourt, Hirsch, Merchan-Perez, De Felipe, Ben-Ari, Esclapez, Bernard (bib8) 2001; 4 Lamusuo, Pitkanen, Jutila, Ylinen, Partanen, Kalviainen, Ruottinen, Oikonen, Nagren, Lehikoinen, Vapalahti, Vainio, Rinne (bib15) 2000; 54 Pike, Halldin, Crouzel, Barre, Nutt, Osman, Shah, Turton, Waters (bib23) 1993; 20 Coulter (bib9) 2001; 45 Tanaka, Tanaka, Fujita, Takano, Fukuda, Sako, Yonemasu (bib30) 1992; 38 Mathern, Cifuentes, Leite, Pretorius, Babb (bib17) 1993; 87 Kobayashi, Buckmaster (bib13) 2003; 23 Schubiger, Hasler, Beer-Wohlfahrt, Bekier, Oettli, Cordes, Ferstl, Deisenhammer, De Roo, Moser, Nitzsche, Podreka, Riccabona, Bangerl, Schober, Bartenstein, Van Isselt, Van Royen, Verhoeff, Haldemann, Von Schulthess (bib28) 1991; 12 Bekenstein, Rempe, Lothman (bib2) 1993; 601 Johnson, de Lanerolle, Kim, Sundaresan, Spencer, Mattson, Zoghbi, Baldwin, Hoffer, Seibyl, Innis (bib12) 1992; 42 Morimoto, Fahnestock, Racine (bib20) 2004; 73 Paxinos, Watson (bib22) 1986 Ryvlin, Bouvard, Le Bars, De Lamerie, Gregoire, Kahane, Froment, Mauguiere (bib25) 1998; 121 Koepp, Richardson, Brooks, Poline, Van Paesschen, Friston, Duncan (bib14) 1996; 119 Henry, Frey, Sackellares, Gilman, Koeppe, Brunberg, Ross, Berent, Young, Kuhl (bib10) 1993; 43 Lothman, Bertram, Kapur, Stringer (bib16) 1990; 6 Rocha, Ondarza-Rovira (bib24) 1999; 262 Paxinos (10.1016/j.eplepsyres.2004.07.011_bib22) 1986 Lothman (10.1016/j.eplepsyres.2004.07.011_bib16) 1990; 6 Brooks-Kayal (10.1016/j.eplepsyres.2004.07.011_bib4) 1998; 4 Kobayashi (10.1016/j.eplepsyres.2004.07.011_bib13) 2003; 23 Burdette (10.1016/j.eplepsyres.2004.07.011_bib6) 1995; 45 Wu (10.1016/j.eplepsyres.2004.07.011_bib32) 2001; 104 Schubiger (10.1016/j.eplepsyres.2004.07.011_bib28) 1991; 12 Ryvlin (10.1016/j.eplepsyres.2004.07.011_bib25) 1998; 121 Rocha (10.1016/j.eplepsyres.2004.07.011_bib24) 1999; 262 Lamusuo (10.1016/j.eplepsyres.2004.07.011_bib15) 2000; 54 Sloviter (10.1016/j.eplepsyres.2004.07.011_bib29) 1991; 1 Henry (10.1016/j.eplepsyres.2004.07.011_bib10) 1993; 43 Cohen (10.1016/j.eplepsyres.2004.07.011_bib7) 2003; 17 Oliva (10.1016/j.eplepsyres.2004.07.011_bib21) 2002; 22 Beer (10.1016/j.eplepsyres.2004.07.011_bib1) 1990; 31 Milgram (10.1016/j.eplepsyres.2004.07.011_bib19) 1991; 551 Matsuda (10.1016/j.eplepsyres.2004.07.011_bib18) 2003; 44 Bekenstein (10.1016/j.eplepsyres.2004.07.011_bib2) 1993; 601 Buckmaster (10.1016/j.eplepsyres.2004.07.011_bib5) 1997; 385 Savic (10.1016/j.eplepsyres.2004.07.011_bib27) 1988; 2 Pike (10.1016/j.eplepsyres.2004.07.011_bib23) 1993; 20 Bekenstein (10.1016/j.eplepsyres.2004.07.011_bib3) 1993; 259 Sata (10.1016/j.eplepsyres.2004.07.011_bib26) 2002; 43 Koepp (10.1016/j.eplepsyres.2004.07.011_bib14) 1996; 119 Johnson (10.1016/j.eplepsyres.2004.07.011_bib12) 1992; 42 Tanaka (10.1016/j.eplepsyres.2004.07.011_bib30) 1992; 38 Johnson (10.1016/j.eplepsyres.2004.07.011_bib11) 1990; 47 Veenman (10.1016/j.eplepsyres.2004.07.011_bib31) 2002; 80 Mathern (10.1016/j.eplepsyres.2004.07.011_bib17) 1993; 87 Morimoto (10.1016/j.eplepsyres.2004.07.011_bib20) 2004; 73 Cossart (10.1016/j.eplepsyres.2004.07.011_bib8) 2001; 4 Coulter (10.1016/j.eplepsyres.2004.07.011_bib9) 2001; 45 |
| References_xml | – volume: 42 start-page: 811 year: 1992 end-page: 815 ident: bib12 article-title: Central and peripheral benzodiazepine receptors: opposite changes in human epileptogenic tissue publication-title: Neurology contributor: fullname: Innis – volume: 121 start-page: 2067 year: 1998 end-page: 2081 ident: bib25 article-title: Clinical utility of Flumazenil-PET versus [ publication-title: Brain contributor: fullname: Mauguiere – volume: 20 start-page: 503 year: 1993 end-page: 525 ident: bib23 article-title: Radioligands for PET studies of central benzodiazepine receptors and PK (peripheral benzodiazepine) binding sites-current status publication-title: Nucl. Med. Biol. contributor: fullname: Waters – volume: 4 start-page: 1166 year: 1998 end-page: 1172 ident: bib4 article-title: Selective changes in single cell GABA-A receptor subunit expression and function in temporal lobe epilepsy publication-title: Nat. Med. contributor: fullname: Coulter – volume: 601 start-page: 111 year: 1993 end-page: 120 ident: bib2 article-title: Decreased heterosynaptic and homosynaptic paired pulse inhibition in the rat hippocampus as a chronic sequela to limbic status epilepticus publication-title: Brain Res. contributor: fullname: Lothman – volume: 87 start-page: 326 year: 1993 end-page: 339 ident: bib17 article-title: Hippocampal EEG excitability and chronic spontaneous seizures are associated with aberrant synaptic reorganization in the rat intrahippocampal kainate model publication-title: Electroencephalogr. Clin. Neurophysiol. contributor: fullname: Babb – volume: 80 start-page: 917 year: 2002 end-page: 927 ident: bib31 article-title: PK 11195 attenuates kainic acid-induced seizures and alterations in peripheral-type benzodiazepine receptor (PBR) protein components in the rat brain publication-title: J. Neurochem. contributor: fullname: Gavish – volume: 47 start-page: 1535 year: 1990 end-page: 1546 ident: bib11 article-title: Receptor binding characterization of the benzodiazepine radio ligand 125I-Ro16-0154: potential probe for SPECT brain imaging publication-title: Life Sci. contributor: fullname: Innis – volume: 385 start-page: 385 year: 1997 end-page: 404 ident: bib5 article-title: Neuron loss, granule cell axon reorganization, and functional changes in the dentate gyrus of epileptic kainate-treated rats publication-title: J. Comp. Neurol. contributor: fullname: Dudek – volume: 31 start-page: 1007 year: 1990 end-page: 1014 ident: bib1 article-title: In vitro and in vivo evaluation of iodine-123-Ro 16-0154: a new imaging agent for SPECT investigations of benzodiazepine receptors publication-title: J. Nucl. Med. contributor: fullname: Schubiger – volume: 43 start-page: 1998 year: 1993 end-page: 2006 ident: bib10 article-title: In vivo cerebral metabolism and central benzodiazepine-receptor binding in temporal lobe epilepsy publication-title: Neurology contributor: fullname: Kuhl – volume: 259 start-page: 97 year: 1993 end-page: 100 ident: bib3 article-title: Dormancy of inhibitory interneurons in a model of temporal lobe epilepsy publication-title: Science contributor: fullname: Lothman – volume: 45 start-page: 237 year: 2001 end-page: 252 ident: bib9 article-title: Epilepsy-associated plasticity in gamma-aminobutyric acid receptor expression, function, and inhibitory synaptic properties publication-title: Int. Rev. Neurobiol. contributor: fullname: Coulter – volume: 38 start-page: 317 year: 1992 end-page: 334 ident: bib30 article-title: Experimental complex partial seizures induced by a microinjection of kainic acid into limbic structures publication-title: Prog. Neurobiol. contributor: fullname: Yonemasu – volume: 119 start-page: 1677 year: 1996 end-page: 1687 ident: bib14 article-title: Cerebral benzodiazepine receptors in hippocampal sclerosis. An objective in vivo analysis publication-title: Brain contributor: fullname: Duncan – volume: 2 start-page: 863 year: 1988 end-page: 866 ident: bib27 article-title: In vivo demonstration of reduced benzodiazepine receptor binding in human epileptic foci publication-title: Lancet contributor: fullname: Widen – volume: 12 start-page: 569 year: 1991 end-page: 582 ident: bib28 article-title: Evaluation of a multicentre study with Iomazenil—a benzodiazepine receptor ligand publication-title: Nucl. Med. Commun. contributor: fullname: Von Schulthess – volume: 44 start-page: 63 year: 2003 ident: bib18 article-title: Multi-center trial with publication-title: Epilepsia contributor: fullname: Torizuka – volume: 23 start-page: 2440 year: 2003 end-page: 2452 ident: bib13 article-title: Reduced inhibition of dentate granule cells in a model of temporal lobe epilepsy publication-title: J. Neurosci. contributor: fullname: Buckmaster – volume: 73 start-page: 1 year: 2004 end-page: 60 ident: bib20 article-title: Kindling and status epilepticus models of epilepsy: rewiring the brain publication-title: Prog. Neurobiol. contributor: fullname: Racine – volume: 43 start-page: 1039 year: 2002 end-page: 1048 ident: bib26 article-title: Quantitative analysis of benzodiazepine receptor in temporal lobe epilepsy: [ publication-title: Epilepsia contributor: fullname: Yonekura – volume: 54 start-page: 2252 year: 2000 end-page: 2260 ident: bib15 article-title: [ publication-title: Neurology contributor: fullname: Rinne – volume: 551 start-page: 236 year: 1991 end-page: 246 ident: bib19 article-title: Changes in inhibitory processes in the hippocampus following recurrent seizures induced by systemic administration of kainic acid. publication-title: Brain Res. contributor: fullname: Racine – volume: 22 start-page: 8052 year: 2002 end-page: 8062 ident: bib21 article-title: Distally directed dendrotoxicity induced by kainic acid in hippocampal interneurons of green fluorescent protein-expressing transgenic mice publication-title: J. Neurosci. contributor: fullname: Swann – volume: 17 start-page: 1607 year: 2003 end-page: 1616 ident: bib7 article-title: Dentate granule cell GABA publication-title: Eur. J. Neurosci. contributor: fullname: Coulter – volume: 6 start-page: 110 year: 1990 end-page: 118 ident: bib16 article-title: Recurrent spontaneous hippocampal seizures in the rat as a chronic sequela to limbic status epilepticus publication-title: Epilepsy Res. contributor: fullname: Stringer – year: 1986 ident: bib22 article-title: The Rat Brain in Stereotaxic Coordinates contributor: fullname: Watson – volume: 262 start-page: 211 year: 1999 end-page: 214 ident: bib24 article-title: Characterization of benzodiazepine receptor binding following kainic acid administration: an autoradiography study in rats publication-title: Neurosci. Lett. contributor: fullname: Ondarza-Rovira – volume: 45 start-page: 934 year: 1995 end-page: 941 ident: bib6 article-title: Temporal lobe central benzodiazepine binding in unilateral mesial temporal lobe epilepsy publication-title: Neurology contributor: fullname: Albin – volume: 4 start-page: 52 year: 2001 end-page: 62 ident: bib8 article-title: Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy publication-title: Nat. Neurosci. contributor: fullname: Bernard – volume: 104 start-page: 379 year: 2001 end-page: 396 ident: bib32 article-title: Enhanced but fragile inhibition in the dentate gyrus in vivo in the kainic acid model of temporal lobe epilepsy: a study using current source density analysis publication-title: Neuroscience contributor: fullname: Leung – volume: 1 start-page: 41 year: 1991 end-page: 66 ident: bib29 article-title: Permanently altered hippocampal structure, excitability, and inhibition after experimental status epilepticus in the rat: the dormant basket cell hypothesis and its possible relevance to temporal lobe epilepsy publication-title: Hippocampus contributor: fullname: Sloviter – volume: 601 start-page: 111 year: 1993 ident: 10.1016/j.eplepsyres.2004.07.011_bib2 article-title: Decreased heterosynaptic and homosynaptic paired pulse inhibition in the rat hippocampus as a chronic sequela to limbic status epilepticus publication-title: Brain Res. doi: 10.1016/0006-8993(93)91701-S contributor: fullname: Bekenstein – volume: 44 start-page: 63 issue: Suppl. 8 year: 2003 ident: 10.1016/j.eplepsyres.2004.07.011_bib18 article-title: Multi-center trial with 123I-Iomazenil SPECT in Japan—Clinical efficacy of localization of epileptic foci in refractory partial epilepsy. publication-title: Epilepsia contributor: fullname: Matsuda – volume: 104 start-page: 379 year: 2001 ident: 10.1016/j.eplepsyres.2004.07.011_bib32 article-title: Enhanced but fragile inhibition in the dentate gyrus in vivo in the kainic acid model of temporal lobe epilepsy: a study using current source density analysis publication-title: Neuroscience doi: 10.1016/S0306-4522(01)00043-4 contributor: fullname: Wu – volume: 43 start-page: 1998 year: 1993 ident: 10.1016/j.eplepsyres.2004.07.011_bib10 article-title: In vivo cerebral metabolism and central benzodiazepine-receptor binding in temporal lobe epilepsy publication-title: Neurology doi: 10.1212/WNL.43.10.1998 contributor: fullname: Henry – volume: 22 start-page: 8052 year: 2002 ident: 10.1016/j.eplepsyres.2004.07.011_bib21 article-title: Distally directed dendrotoxicity induced by kainic acid in hippocampal interneurons of green fluorescent protein-expressing transgenic mice publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.22-18-08052.2002 contributor: fullname: Oliva – volume: 47 start-page: 1535 year: 1990 ident: 10.1016/j.eplepsyres.2004.07.011_bib11 article-title: Receptor binding characterization of the benzodiazepine radio ligand 125I-Ro16-0154: potential probe for SPECT brain imaging publication-title: Life Sci. doi: 10.1016/0024-3205(90)90182-Q contributor: fullname: Johnson – volume: 12 start-page: 569 year: 1991 ident: 10.1016/j.eplepsyres.2004.07.011_bib28 article-title: Evaluation of a multicentre study with Iomazenil—a benzodiazepine receptor ligand publication-title: Nucl. Med. Commun. doi: 10.1097/00006231-199107000-00002 contributor: fullname: Schubiger – volume: 4 start-page: 52 year: 2001 ident: 10.1016/j.eplepsyres.2004.07.011_bib8 article-title: Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy publication-title: Nat. Neurosci. doi: 10.1038/82900 contributor: fullname: Cossart – volume: 2 start-page: 863 year: 1988 ident: 10.1016/j.eplepsyres.2004.07.011_bib27 article-title: In vivo demonstration of reduced benzodiazepine receptor binding in human epileptic foci publication-title: Lancet doi: 10.1016/S0140-6736(88)92468-3 contributor: fullname: Savic – volume: 119 start-page: 1677 year: 1996 ident: 10.1016/j.eplepsyres.2004.07.011_bib14 article-title: Cerebral benzodiazepine receptors in hippocampal sclerosis. An objective in vivo analysis publication-title: Brain doi: 10.1093/brain/119.5.1677 contributor: fullname: Koepp – volume: 31 start-page: 1007 year: 1990 ident: 10.1016/j.eplepsyres.2004.07.011_bib1 article-title: In vitro and in vivo evaluation of iodine-123-Ro 16-0154: a new imaging agent for SPECT investigations of benzodiazepine receptors publication-title: J. Nucl. Med. contributor: fullname: Beer – volume: 54 start-page: 2252 year: 2000 ident: 10.1016/j.eplepsyres.2004.07.011_bib15 article-title: [11C] Flumazenil binding in the medial temporal lobe in patients with temporal lobe epilepsy: correlation with hippocampal MR volumetry, T2 relaxometry, and neuropathology publication-title: Neurology doi: 10.1212/WNL.54.12.2252 contributor: fullname: Lamusuo – volume: 80 start-page: 917 year: 2002 ident: 10.1016/j.eplepsyres.2004.07.011_bib31 article-title: PK 11195 attenuates kainic acid-induced seizures and alterations in peripheral-type benzodiazepine receptor (PBR) protein components in the rat brain publication-title: J. Neurochem. doi: 10.1046/j.0022-3042.2002.00769.x contributor: fullname: Veenman – volume: 23 start-page: 2440 year: 2003 ident: 10.1016/j.eplepsyres.2004.07.011_bib13 article-title: Reduced inhibition of dentate granule cells in a model of temporal lobe epilepsy publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.23-06-02440.2003 contributor: fullname: Kobayashi – volume: 87 start-page: 326 year: 1993 ident: 10.1016/j.eplepsyres.2004.07.011_bib17 article-title: Hippocampal EEG excitability and chronic spontaneous seizures are associated with aberrant synaptic reorganization in the rat intrahippocampal kainate model publication-title: Electroencephalogr. Clin. Neurophysiol. doi: 10.1016/0013-4694(93)90186-Y contributor: fullname: Mathern – volume: 4 start-page: 1166 year: 1998 ident: 10.1016/j.eplepsyres.2004.07.011_bib4 article-title: Selective changes in single cell GABA-A receptor subunit expression and function in temporal lobe epilepsy publication-title: Nat. Med. doi: 10.1038/2661 contributor: fullname: Brooks-Kayal – volume: 20 start-page: 503 year: 1993 ident: 10.1016/j.eplepsyres.2004.07.011_bib23 article-title: Radioligands for PET studies of central benzodiazepine receptors and PK (peripheral benzodiazepine) binding sites-current status publication-title: Nucl. Med. Biol. doi: 10.1016/0969-8051(93)90082-6 contributor: fullname: Pike – volume: 262 start-page: 211 year: 1999 ident: 10.1016/j.eplepsyres.2004.07.011_bib24 article-title: Characterization of benzodiazepine receptor binding following kainic acid administration: an autoradiography study in rats publication-title: Neurosci. Lett. doi: 10.1016/S0304-3940(99)00080-4 contributor: fullname: Rocha – volume: 551 start-page: 236 year: 1991 ident: 10.1016/j.eplepsyres.2004.07.011_bib19 article-title: Changes in inhibitory processes in the hippocampus following recurrent seizures induced by systemic administration of kainic acid. publication-title: Brain Res. doi: 10.1016/0006-8993(91)90938-R contributor: fullname: Milgram – volume: 121 start-page: 2067 year: 1998 ident: 10.1016/j.eplepsyres.2004.07.011_bib25 article-title: Clinical utility of Flumazenil-PET versus [18F] fluorodeoxyglucose-PET and MRI in refractory partial epilepsy publication-title: Brain doi: 10.1093/brain/121.11.2067 contributor: fullname: Ryvlin – volume: 73 start-page: 1 year: 2004 ident: 10.1016/j.eplepsyres.2004.07.011_bib20 article-title: Kindling and status epilepticus models of epilepsy: rewiring the brain publication-title: Prog. Neurobiol. doi: 10.1016/j.pneurobio.2004.03.009 contributor: fullname: Morimoto – volume: 45 start-page: 934 year: 1995 ident: 10.1016/j.eplepsyres.2004.07.011_bib6 article-title: Temporal lobe central benzodiazepine binding in unilateral mesial temporal lobe epilepsy publication-title: Neurology doi: 10.1212/WNL.45.5.934 contributor: fullname: Burdette – volume: 385 start-page: 385 year: 1997 ident: 10.1016/j.eplepsyres.2004.07.011_bib5 article-title: Neuron loss, granule cell axon reorganization, and functional changes in the dentate gyrus of epileptic kainate-treated rats publication-title: J. Comp. Neurol. doi: 10.1002/(SICI)1096-9861(19970901)385:3<385::AID-CNE4>3.0.CO;2-# contributor: fullname: Buckmaster – volume: 6 start-page: 110 year: 1990 ident: 10.1016/j.eplepsyres.2004.07.011_bib16 article-title: Recurrent spontaneous hippocampal seizures in the rat as a chronic sequela to limbic status epilepticus publication-title: Epilepsy Res. doi: 10.1016/0920-1211(90)90085-A contributor: fullname: Lothman – volume: 42 start-page: 811 year: 1992 ident: 10.1016/j.eplepsyres.2004.07.011_bib12 article-title: Central and peripheral benzodiazepine receptors: opposite changes in human epileptogenic tissue publication-title: Neurology doi: 10.1212/WNL.42.4.811 contributor: fullname: Johnson – volume: 1 start-page: 41 year: 1991 ident: 10.1016/j.eplepsyres.2004.07.011_bib29 article-title: Permanently altered hippocampal structure, excitability, and inhibition after experimental status epilepticus in the rat: the dormant basket cell hypothesis and its possible relevance to temporal lobe epilepsy publication-title: Hippocampus doi: 10.1002/hipo.450010106 contributor: fullname: Sloviter – volume: 17 start-page: 1607 year: 2003 ident: 10.1016/j.eplepsyres.2004.07.011_bib7 article-title: Dentate granule cell GABAA receptors in epileptic hippocampus: enhanced synaptic efficacy and altered pharmacology publication-title: Eur. J. Neurosci. doi: 10.1046/j.1460-9568.2003.02597.x contributor: fullname: Cohen – volume: 259 start-page: 97 year: 1993 ident: 10.1016/j.eplepsyres.2004.07.011_bib3 article-title: Dormancy of inhibitory interneurons in a model of temporal lobe epilepsy publication-title: Science doi: 10.1126/science.8093417 contributor: fullname: Bekenstein – volume: 43 start-page: 1039 year: 2002 ident: 10.1016/j.eplepsyres.2004.07.011_bib26 article-title: Quantitative analysis of benzodiazepine receptor in temporal lobe epilepsy: [125I] Iomazenil autoradiographic study of surgically resected specimens publication-title: Epilepsia doi: 10.1046/j.1528-1157.2002.137601.x contributor: fullname: Sata – volume: 45 start-page: 237 year: 2001 ident: 10.1016/j.eplepsyres.2004.07.011_bib9 article-title: Epilepsy-associated plasticity in gamma-aminobutyric acid receptor expression, function, and inhibitory synaptic properties publication-title: Int. Rev. Neurobiol. doi: 10.1016/S0074-7742(01)45013-6 contributor: fullname: Coulter – volume: 38 start-page: 317 year: 1992 ident: 10.1016/j.eplepsyres.2004.07.011_bib30 article-title: Experimental complex partial seizures induced by a microinjection of kainic acid into limbic structures publication-title: Prog. Neurobiol. doi: 10.1016/0301-0082(92)90023-8 contributor: fullname: Tanaka – year: 1986 ident: 10.1016/j.eplepsyres.2004.07.011_bib22 contributor: fullname: Paxinos |
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