NATRIURETIC PEPTIDE AND HIS PROGENITORS AS PREDICTORS OF PROGRESSIVE POSTOPERATIVE LEFT VENTRICLE REMODELING IN PATIENTS WITH ISCHEMIC CARDIOMYOPATHY

• Published in: Bi͡u︡lletenʹ Sibirskoĭ medit͡s︡iny Vol. 12; no. 6; pp. 23 - 30
• Main Authors: Gutor, S. S., Kazakov, V. A., Suhodolo, I. V., Shipulin, V. M., Babokin, V. Ye, Ogurkova, O. N., Andreyev, S. L., Safonova, A. V.
• Format: Journal Article
• Language: English
• Published: Siberian State Medical University (Tomsk) 28.12.2013
• Subjects: ишемическая кардиомиопатия, натрийуретический пептид, image j
• ISSN: 1682-0363; 1819-3684
• DOI: 10.20538/1682-0363-2013-6-23-30

The work is devoted to the study of atrial natriuretic peptide (ANP) and its precursors as one of possible predictors of left ventricular repeated remodeling in patients with ischemic cardiomyopathy (ICMP) in the follow-up (postoperative period). Objects of the study are venous blood and intraoperative samples of right atrial auricle. Precursors of NUP were identified in blood serum by the immuno-fluorescence test. Ultrathin slices of auricle biopsy samples were examined with electronmicroscopy with the use of image processing ImageJ software (program). The concentration of NUP precursors in blood plasma and relation of minimal diameter of secretory granules to maximal one in right auricle cardiomyocytes reflect pathological processes taking place in the myocardium of patients with ICMP. Ratio of minimal and maximal diameters of secretory granules is a predictor of chronic heart failure progressing.