Synthesis, antioxidant and anti-inflammatory activity of novel arylacetic and aryl-hydroxamic acids

Four new aryl-acetic acids and the corresponding hydroxamic acids were synthesized. These compounds showed interesting interaction with the free radical 1,1diphenyl-2-picryl-hydrazyl (DPPH), scavenging activity on 011, inhibition of soybean lipoxygenase and a significant inhibition of carrageenin in...

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Bibliographic Details
Published inArzneimittel-Forschung Vol. 53; no. 11; pp. 780 - 785
Main Authors Pontiki, EA, Hadjipavlou-Litina, DJ
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 25.12.2011
Subjects
Chemistry
Chemistry, Medicinal
Chemistry, Multidisciplinary
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Physical Sciences
Science & Technology
hydroxamic acids, anti-inflammatory activity, antioxidant activity, synthesis
radicals
DRUGS
5-LIPOXYGENASE
INHIBITORS
anti-inflammatories
lipoxygenase inhibitors
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Summary:Four new aryl-acetic acids and the corresponding hydroxamic acids were synthesized. These compounds showed interesting interaction with the free radical 1,1diphenyl-2-picryl-hydrazyl (DPPH), scavenging activity on 011, inhibition of soybean lipoxygenase and a significant inhibition of carrageenin induced paw edema in rats (44.1 - 70.9%) at a concentration of 0.01 mmol/100g.
ISSN:0004-4172
1616-7066
DOI:10.1055/s-0031-1299829