Synthesis, antioxidant and anti-inflammatory activity of novel arylacetic and aryl-hydroxamic acids
Four new aryl-acetic acids and the corresponding hydroxamic acids were synthesized. These compounds showed interesting interaction with the free radical 1,1diphenyl-2-picryl-hydrazyl (DPPH), scavenging activity on 011, inhibition of soybean lipoxygenase and a significant inhibition of carrageenin in...
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Published in | Arzneimittel-Forschung Vol. 53; no. 11; pp. 780 - 785 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
STUTTGART
Thieme Medical Publishers
25.12.2011
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Subjects | |
Online Access | Get more information |
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Summary: | Four new aryl-acetic acids and the corresponding hydroxamic acids were synthesized. These compounds showed interesting interaction with the free radical 1,1diphenyl-2-picryl-hydrazyl (DPPH), scavenging activity on 011, inhibition of soybean lipoxygenase and a significant inhibition of carrageenin induced paw edema in rats (44.1 - 70.9%) at a concentration of 0.01 mmol/100g. |
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ISSN: | 0004-4172 1616-7066 |
DOI: | 10.1055/s-0031-1299829 |