Fuel‐Selective Transient Activation of Nanosystems for Signal Generation

The transient activation of function using chemical fuels is common in nature, but much less in synthetic systems. Progress towards the development of systems with a complexity similar to that of natural ones requires chemical fuel selectivity. Here, we show that a self‐assembled nanosystem, compose...

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Bibliographic Details
Published inAngewandte Chemie Vol. 130; no. 6; pp. 1627 - 1631
Main Authors della Sala, Flavio, Maiti, Subhabrata, Bonanni, Andrea, Scrimin, Paolo, Prins, Leonard J.
Format Journal Article
LanguageEnglish
German
Published Weinheim Wiley Subscription Services, Inc 05.02.2018
Subjects
Activation
Chemical fuels
Chemistry
Dissipative Selbstorganisation
Fluoreszenz
Gold
Gold-Nanopartikel
Nanoparticles
Recognition
Selectivity
Self-assembly
Signal generation
Supramolekulare Chemie
Systemchemie
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Summary:The transient activation of function using chemical fuels is common in nature, but much less in synthetic systems. Progress towards the development of systems with a complexity similar to that of natural ones requires chemical fuel selectivity. Here, we show that a self‐assembled nanosystem, composed of monolayer‐protected gold nanoparticles and a fluorogenic peptide, is activated for transient signal generation only in case the chemical fuel matches the recognition site present at the nanoparticle surface. A modification of the recognition site in the nanosystem completely changes the chemical fuel selectivity. When two nanosystems are simultaneously present, the selectivity expressed by the system depends on the concentration of nucleotide added. Nur mit dem richtigen Brennstoff: Die transiente Aktivierung einer Funktion mit chemischen Brennstoffen ist in der Natur weit verbreitet, kommt in synthetischen Systemen aber kaum vor. Ein System wurde entwickelt, das transiente Signale nur dann erzeugt, wenn der chemische Brennstoff in das Erkennungszentrum von monoschichtgeschützten Gold‐Nanopartikeln passt.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201711964