Immunometabolic Associations in Diseases of Complex Genesis

In the estimation of immunobiochemical indices and the use of formalized statistics, clinical models of ischemic and hemorrhagic strokes aggravated by metabolic syndrome and of diffuse liver diseases have demonstrated the formation (under the influence of metabolic syndrome) of a reaction that is qu...

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Bibliographic Details
Published inBiology bulletin reviews Vol. 10; no. 4; pp. 280 - 284
Main Authors Zemskov, A. M., Zemskov, V. M., Luzky, M. A., Popov, S. S., Pashkov, A. N., Zemskova, V. A.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 2020
Springer Nature B.V
Subjects
Antioxidants
Apoptosis
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cytokines
Ecology
Free radicals
Hemorrhage
Immune status
Inflammation
Ischemia
Life Sciences
Lipid metabolism
Liver diseases
Metabolic syndrome
Oxidative stress
Statistical analysis
Stroke
Zoology
metabolism
immunity
hepatitis
stroke
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Summary:In the estimation of immunobiochemical indices and the use of formalized statistics, clinical models of ischemic and hemorrhagic strokes aggravated by metabolic syndrome and of diffuse liver diseases have demonstrated the formation (under the influence of metabolic syndrome) of a reaction that is qualitatively homogeneous and quantitatively more pronounced with hemorrhagic stroke in the form of an imbalance in the primary and secondary products of free radical oxidation of lipids and proteins; the preferential activation of enzymatic and nonenzymatic mechanisms of the antioxidant system against a background of an accumulation of proinflammatory cytokines, and, in patients with diffuse liver diseases, the presence of a universal mechanism of the association of the intensity of oxidative stress (free radical oxidation) with the development of cytolytic syndrome, disorders of lipid metabolism, immune status, and the initiation of apoptosis mechanisms.
ISSN:2079-0864
2079-0872
DOI:10.1134/S2079086420040118