Isoniazid associated psychosis: case series from a tertiary care centre

Isoniazid (INH) is a commonly used first line antitubercular drug. INH associated psychosis is a rare psychiatric manifestation. We report two cases of pulmonary tuberculosis, where the patients developed psychosis after being given a therapeutic dose of INH. In vulnerable patients, INH may cause ch...

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Published inOpen journal of psychiatry & allied sciences Vol. 9; no. 2; pp. 161 - 163
Main Authors Singh, Hemendra, Devi, HJ Gayathri, Chabaria, Mamatha, Shekar, Kartik
Format Journal Article
LanguageEnglish
Published Academy Publisher 01.07.2018
Subjects
Antipsychotic Agents
Antitubercular Agents
Pyridoxine
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Summary:Isoniazid (INH) is a commonly used first line antitubercular drug. INH associated psychosis is a rare psychiatric manifestation. We report two cases of pulmonary tuberculosis, where the patients developed psychosis after being given a therapeutic dose of INH. In vulnerable patients, INH may cause change in concentration of neurotransmitters by inhibition of monoamine oxidase (MAO) and deficiency of pyridoxine. This might precipitate psychosis. Our observation also supports the hypothesis that INH associated psychotic disorders might have a pathophysiological substrate in common with some schizophrenia patients, who show remarkable response to low doses of atypical antipsychotic agents and pyridoxine supplementation.
ISSN:2394-2053
2394-2061
DOI:10.5958/2394-2061.2018.00019.8