Healing of a skin wound when using Trigonella foenum‑graecum against the background of experimental steroid hyperglycemia

• Published in: Issledovaniâ i praktika v medicine Vol. 10; no. 2; pp. 70 - 79
• Main Authors: L. A. Balykova, V. I. Inchina, T. V. Tarasova, G. I. Myandina, D. A. Khaydar, E. A. Korovyakova, L. M. Mosina, I. V. Saushev, R. S. Tarasov, G. A. Bayburina, D. E. Bayburina, I. E. Trubitsyna
• Format: Journal Article
• Language: English; Russian
• Published: QUASAR, LLC 01.06.2023
• Subjects: diabetic foot; experiment; infected skin wound; regeneration; steroid hyperglycemia; trigonella foenum‑graecum (fenugreek); type 2 diabetes mellitus
• ISSN: 2410-1893
• DOI: 10.17709/2410-1893-2023-10-2-7

Purpose. To evaluate the intensity of healing of an infected skin wound in rats using Trigonella foenum- graecum (Fenugreek) against the background of experimental steroid hyperglycemia.Materials and methods. The rats included in the study (n = 20) were divided into two equal groups. First, a model of steroid hyperglycemia was created for all animals. Then the same animals (n = 20) were used to create models of infected skin wound. The rats of the first group (the main one) were treated with wound surface ointment containing Trigonella foenum- graecum. Also, Trigonella foenum- graecum extract was constantly added to the water for the rats of the first group. Intact vaseline ointment was applied to the wound of the second group (control) rats. After 5 days, we evaluated the wound regeneration activity, blood glucose levels, and blood panel in all animals.Results. This study showed several positive aspects of the use of Trigonella foenum-g raecum in terms of treatment of infected skin wounds in animals with steroid hyperglycemia. The decrease in glucose levels almost to baseline values in the rats of the main group against the background of oral administration of Trigonella foenum-g raecum was recorded. By the end of the observation, the level of glycemia was almost two times less in animals of the first group compared to the second (p < 0.05). In animals of the first group, the number of leukocytes was higher compared to the second group, but this difference was not significant. However, we recorded a significant increase in the number of granulocytes by more than two times (p < 0.05), which indicates the immunomodulatory property of Trigonella foenum- graecum, which affected the regeneration activity of the infected wound in a positive way in rats of the first group.Conclusion. As a result of this study, promising prospects have been obtained for the use of the plant‑ derived drug Trigonella foenum- graecum in the correction of hyperglycemia and the treatment of infected wounds. Application of fenugreek topically in the form of an extract reduced inflammation and improved wound healing in rats suffering from steroid hyperglycemia.