Antibacterial and Cytotoxic Effects of Multi-Walled Carbon Nanotubes Functionalized with Iodine

• Published in: Nanobiotechnology Reports (Online) Vol. 17; no. 2; pp. 184 - 192
• Main Authors: Belova, V. V., Zakharova, O. V., Stolyarov, R. A., Gusev, A. A., Vasyukova, I. A., Baranchikov, P. A., Memetova, A. E., Chapaksov, N. A.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 2022; Springer Nature B.V
• Subjects: Bacteria; Chemistry and Materials Science; Coliforms; Cytotoxicity; E coli; Industrial and Production Engineering; Iodine; Machines; Manufacturing; Materials Science; Multi wall carbon nanotubes; Nanobiology and Genetics; Nanotechnology; Omics; Processes; Survival
• ISSN: 2635-1676; 1995-0780; 2635-1684; 1995-0799
• DOI: 10.1134/S2635167622020033

The effect of multi-walled carbon nanotubes (MWCNTs) functionalized with iodine (15, 10, and 5 wt %) is studied for bacteria Escherichia coli and MCF-7 breast adenocarcinoma tumor cells. A significant increase in the antimicrobial activity of MWCNTs is obtained when they are modified with 15 and 10 wt % iodine: at concentrations of 0.1 and 0.01 g/L, the survival of bacteria was less than 2%, while for MWCNTs without iodine, the indicator was 7 and 30%, respectively. The modification of MWCNTs with 5-wt % iodine also enhances the antibacterial properties of nanotubes, but less significantly. MCF-7 cells also have the greatest cytotoxic effect on MWCNTs functionalized with 15- and 10-wt % iodine; however, unlike bacteria, the difference in the survival rates between composites and compared with pure MWCNTs was no more than 3%. Comparison of the effects of iodine in MWCNTs and pure iodine showed that functionalized MWCNTs at concentrations above 0.001 g/L are more toxic to bacteria, while pure iodine solutions are more cytotoxic to cells.