Use of Diazepam to Correct Hemodynamic Changes in Explosive Mine Injury: Experimental Study

• Published in: Obshchai͡a︡ reanimatologii͡a Vol. 3; no. 2; pp. 9 - 12
• Main Authors: Yelsky, V. N., Krivobok, G. K., Antonov, Ye. V.
• Format: Journal Article
• Language: English
• Published: Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia 20.04.2007
• Subjects: diazepam; explosive injury; hemodynamics
• ISSN: 1813-9779; 2411-7110
• DOI: 10.15360/1813-9779-2007-2-9-12

Objective. To study the hemodynamic effect of benzodiazepine tranquilizers in explosive mine injury in an experiment.Materials and methods. The study was performed on non-inbred male rats; hemodynamic parameters were examined at the systemic, organ, and microcirculatory levels.Results. Circulatory adaptive changes occurring at the beginning of a premorbid load further become pathogenic, which in combination with a progressive change in blood-brain barrier resistance results in the severer course of premorbid load-complicated explosive mine injury than that of isolated one. Correction of occurring disorders, by stimulating the stress-limiting GABAergic system with diazepam, is most effective within the first 25 minutes after isolated explosive mine injury and within the first 15 minutes after complicated one. Conclusion. Under the conditions of deep collieries where medical aid was generally late, emergency medical activation of urgent adaptation mechanisms by the techniques specially developed by the authors for these conditions is the most effective way of preventing the complications of explosive mine injury.