Palladium-catalyzed cross-coupling reactions of 7-bromo-2,3-diphenylpyrido[2,3-b]pyrazine

First examples of palladium-catalyzed cross-coupling reactions, such as Suzuki, Sonogashira, Heck and Buchwald-Hartwig reactions, are reported in the pyrido[2,3-b]pyrazine series. This methodology circumvents problems found in uncatalyzed nucleophilic substitution used so far to introduce substituen...

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Bibliographic Details
Published inSynthesis (Stuttgart) no. 8; pp. 1345 - 1349
Main Authors Yin, LX, Liebscher, J
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 20.05.2005
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
synthesis
palladium catalysis
COMPLEXES
ELECTROCHEMICAL REDUCTION
RECEPTOR
pyrido[2,3-b]pyrazine
5-AMINOMETHYLQUINOXALINE-2,3-DIONES
POTENT
heterocycles
DNA
cross-coupling
QUINOXALINES
FOLATE
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Summary:First examples of palladium-catalyzed cross-coupling reactions, such as Suzuki, Sonogashira, Heck and Buchwald-Hartwig reactions, are reported in the pyrido[2,3-b]pyrazine series. This methodology circumvents problems found in uncatalyzed nucleophilic substitution used so far to introduce substituents into the pyrido[2,3-b]pyrazine ring.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2005-861871