Kinetics of periodate oxidation of polyoxyethylene – 300, a biodegradable pharmaceutical polymer

Polyoxyethylene Oxide – 300 (POE) is a well-known biodegradable pharmaceutical polymer. In order to understand the stability of POE and to derive the reaction rate law, the title reaction was carried out in aqueous alkaline medium, Reaction was found to be first order dependent on the concentration...

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Bibliographic Details
Published inInternational journal of research in pharmaceutical sciences Vol. 10; no. 4; pp. 2830 - 2836
Main Authors Koteswara Rao K.V.S, Venkata Nadh R, Venkata Ratnam K
Format Journal Article
LanguageEnglish
Published 16.10.2019
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Summary:Polyoxyethylene Oxide – 300 (POE) is a well-known biodegradable pharmaceutical polymer. In order to understand the stability of POE and to derive the reaction rate law, the title reaction was carried out in aqueous alkaline medium, Reaction was found to be first order dependent on the concentration oxidant (periodate) and independent of substrate (POE) concentration. A retardation of reaction rate with an increase in hydroxide concentration shows an inverse fractional order in it. Based on the studies of the temperature dependence of reaction, evaluated the activation parameters.
ISSN:0975-7538
0975-7538
DOI:10.26452/ijrps.v10i4.1558