Two autopsy cases of hepatic fungal abscesses associated with acute leukemia

• Published in: Kanzo Vol. 25; no. 11; pp. 1474 - 1482
• Main Authors: KOYATA, Hirohisa, NANBU, Shuji, SHIMIZU, Yukihiro, MIYABAYASHI, Chiharu, ICHIDA, Takafumi, NAKANO, Mamoru, INOUE, Kyouichi, SASAKI, Hiroshi, WAKAGI, Kunihiko, KOIZUMI, Tomiasa
• Format: Journal Article
• Language: Japanese
• Published: The Japan Society of Hepatology 1984
• ISSN: 0451-4203; 1881-3593
• DOI: 10.2957/kanzo.25.1474

Two autopsy cases of hepatic fungal abscesses in acute leukemia were presented. The first case was a 48-year-old female patient with acute promyelocytic leukemia. She was treated with intensive chemotherapy. Her clinical course was complicated by high fever, jaundice and hypoalbuminemia. In spite of jaundice, serum transaminase levels remained in almost normal range. She was suffered from pneumonia and died of respiratory failure. Necropsy revealed hepatic fungal abscesses caused by Candida species. The second case was a 59-year-old male patient with acute myelomonocytic leukemia. His clinical course was similar to the first case. Necropsy showed hepatic abscesses caused by Mucor species. Recently, the incidence of deep mycoses has been increasing because of combination therapy of newly deviced antibiotics, anticancer agents and corticosteroid. It is necessary for us to consider the presence of hepatic fungal abscesses if high fever and liver dysfunction develop in a neutropenic patient with acute leukemia.