Advances in Blood Biomarkers and Diagnosis Approaches for Neurodegenerative Dementias and Related Diseases

Neurodegenerative dementias and related diseases, such as Alzheimer's disease, dementia with Lewy bodies, and Parkinson's disease have no fundamental cure yet. Degenerative proteins begin to accumulate before the onset of the symptoms of these diseases, and the early detection of these sym...

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Published inJournal of integrative neuroscience Vol. 23; no. 10; p. 188
Main Authors Sekimori, Tomoki, Fukunaga, Kohji, Finkelstein, David I, Kawahata, Ichiro
Format Journal Article
LanguageEnglish
Published Singapore IMR Press 10.10.2024
Subjects
Alzheimer Disease - blood
Alzheimer Disease - cerebrospinal fluid
Alzheimer Disease - diagnosis
Biomarkers - blood
blood biomarkers
dementia
Dementia - blood
Dementia - diagnosis
diagnosis
discrimination technique
Humans
Lewy Body Disease - blood
Lewy Body Disease - cerebrospinal fluid
Lewy Body Disease - diagnosis
neurodegenerative disease
Neurodegenerative Diseases - blood
Neurodegenerative Diseases - cerebrospinal fluid
Neurodegenerative Diseases - diagnosis
Parkinson Disease - blood
Parkinson Disease - cerebrospinal fluid
Parkinson Disease - diagnosis
dementia
diagnosis
blood biomarkers
neurodegenerative disease
discrimination technique
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Summary:Neurodegenerative dementias and related diseases, such as Alzheimer's disease, dementia with Lewy bodies, and Parkinson's disease have no fundamental cure yet. Degenerative proteins begin to accumulate before the onset of the symptoms of these diseases, and the early detection of these symptoms can lead to early therapeutic intervention. Therefore, early and simpler diagnostic methods are required. This review focuses on blood biomarkers, which are less expensive and easier to use than cerebrospinal fluid biomarkers and diagnostic imaging. A variety of approaches exist for establishing diagnostic methods for neurodegenerative dementias using blood biomarkers, such as disease differentiation using a single molecule, methods that combine multiple biomarkers, studies that search for important markers by comprehensively analyzing many molecules, and methods that combine other data. Finally, we discuss the future prospects for blood biomarker research based on the characteristics of each approach.
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ISSN:0219-6352
1757-448X
DOI:10.31083/j.jin2310188