Cu (I) Catalyzed One Pot S-N-Click Reactions of Halogenated Coumarins and 1-aza-coumarins

A one pot three component, copper catalyzed azide-alkyne cycloaddition reaction has been employed for the synthesis of bis-coumarinyl triazoles (A-D) using 4-chloro, 4-bromomethyl, 3-bromoacetyl and 4-bromomethyl-1-aza-coumarins (I-IV), sodium azide, and coumarin propargyl ethers (V-IX) in moderate...

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Bibliographic Details
Published inJournal of heterocyclic chemistry Vol. 55; no. 2; pp. 537 - 544
Main Authors Revankar, Hrishikesh M., Kulkarni, Manohar V.
Format Journal Article
LanguageEnglish
Published HOBOKEN Wiley 01.02.2018
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
CYCLOADDITION
ALKYNES
AZIDE
ACIDS
1,2,3-TRIAZOLES
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Summary:A one pot three component, copper catalyzed azide-alkyne cycloaddition reaction has been employed for the synthesis of bis-coumarinyl triazoles (A-D) using 4-chloro, 4-bromomethyl, 3-bromoacetyl and 4-bromomethyl-1-aza-coumarins (I-IV), sodium azide, and coumarin propargyl ethers (V-IX) in moderate yields.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.3090