Nuclear Ptdlns(3,4,5)P 3 signaling: An ongoing story

Abstract Phosphatidylinositol 3,4,5‐ tri sphosphate (Ptdlns(3,4,5)P 3 ) is linked to a variety of cellular functions, such as growth, cell survival, and differentiation. Ptdlns(3,4,5)P 3 is primarily synthesized by class I phosphoinositide 3‐kinases and its hydrolysis by two 3‐phosphoinositide 3‐pho...

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Published inJournal of cellular biochemistry Vol. 98; no. 3; pp. 469 - 485
Main Authors Déléris, Paul, Gayral, Stéphanie, Breton‐Douillon, Monique
Format Journal Article
LanguageEnglish
Published 01.06.2006
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Summary:Abstract Phosphatidylinositol 3,4,5‐ tri sphosphate (Ptdlns(3,4,5)P 3 ) is linked to a variety of cellular functions, such as growth, cell survival, and differentiation. Ptdlns(3,4,5)P 3 is primarily synthesized by class I phosphoinositide 3‐kinases and its hydrolysis by two 3‐phosphoinositide 3‐phosphatases, PTEN and SHIP proteins, leads to the production of two other second messengers, Ptdlns(4,5)P 2 and Ptdlns(3,4)P 2 , respectively. Evidence accumulated over the last years strongly suggest that Ptdlns(3,4,5)P 3 is an important component of signaling pathway operating within the nucleus. Moreover, recent advances indicated that nuclear translocation of cell surface receptors could activate nuclear phosphoinositide 3‐kinase suggesting a new mode of signal transduction. The aim of this review is intended to summarize the state of our knowledge on nuclear Ptdlns(3,4,5)P 3 and its metabolizing enzymes, and to highlight the emerging roles for intranuclear Ptdlns(3,4,5)P 3 . J. Cell. Biochem. 98: 469–485, 2006. © 2006 Wiley‐Liss, Inc.
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.20695